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Study · Non-randomized trial · n = 18 · 1986

4 results

Efficacy of DSIP to normalize sleep in middle-aged and elderly chronic insomniacs.

Schneider-Helmert D

European neurology1 Jan 1986Cited by 1 (Europe PMC)

PMID3792404 (opens in a new tab)DOI10.1159/000116050 (opens in a new tab)PepBankPUB-03792404
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In the whole sample of chronic insomniacs, sleep patterns were normal at the end of the investigation.

    In plain wordsIn the whole group of people with chronic insomnia, sleep patterns were normal at the end of the study.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSleep pattern at end of investigation, whole sample
    Study

    n = 18

    Outcome group
    Sleep · Sleep
    Studied dose
    6 X 30 nmol/kg b.w. · intravenous · 1 week administration, 1 week follow-upAs given in this study (human).

    Source sentences

    Summary
    The whole sample of insomniacs showed normal sleep patterns at the end of the investigation.
    2 context sentences
    Summary · context
    The immediate effects of one week of Delta Sleep-Inducing Peptide (DSIP) administration (6 X 30 nmol/kg b.w., i.v.) and late effects after a follow-up period of one week were investigated in a sleep laboratory study.
    Summary · context
    The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs.
  2. 02HumanNon-randomized trialEfficacy outcome

    In middle-aged chronic insomniacs, sleep improved to normal values by the end of DSIP administration and stayed normal during the follow-up week.

    In plain wordsIn middle-aged people with chronic insomnia, sleep returned to normal values after DSIP and stayed normal for a week.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSleep normalization in middle-aged insomniacs
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    6 X 30 nmol/kg b.w. · intravenous · 1 week administration, 1 week follow-upAs given in this study (human).

    Source sentences

    Summary
    In the middle-aged insomniacs, improvement of sleep to normal values occurred by the end of DSIP administration and was maintained during the follow-up week.
    2 context sentences
    Summary · context
    The immediate effects of one week of Delta Sleep-Inducing Peptide (DSIP) administration (6 X 30 nmol/kg b.w., i.v.) and late effects after a follow-up period of one week were investigated in a sleep laboratory study.
    Summary · context
    The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs.
  3. 03HumanNon-randomized trialEfficacy outcome

    In elderly chronic insomniacs, who had a more severe initial sleep disturbance, the immediate effect of DSIP was larger, but full normalization of sleep came only by the end of the follow-up period.

    In plain wordsIn older people with chronic insomnia, DSIP had a larger immediate effect, but sleep became fully normal only after the follow-up week.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSleep normalization in elderly insomniacs
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    6 X 30 nmol/kg b.w. · intravenous · 1 week administration, 1 week follow-upAs given in this study (human).

    Source sentences

    Summary
    In the elderly insomniacs, who showed an initial sleep disturbance double as severe as the middle-aged group, the immediate effect was larger, but full normalization of sleep was only obtained by the end of the follow-up period.
    2 context sentences
    Summary · context
    The immediate effects of one week of Delta Sleep-Inducing Peptide (DSIP) administration (6 X 30 nmol/kg b.w., i.v.) and late effects after a follow-up period of one week were investigated in a sleep laboratory study.
    Summary · context
    The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs.
  4. 04HumanNon-randomized trialOther

    In chronic insomniacs, a regression analysis showed that the effects of DSIP correlated with the degree of sleep disturbance.

    In plain wordsIn people with chronic insomnia, the effect of DSIP was linked to how severe the sleep problem was at the start.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableRelation of DSIP effect to degree of sleep disturbance
    Study

    n: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    6 X 30 nmol/kg b.w. · intravenous · 1 week administration, 1 week follow-upAs given in this study (human).

    Source sentences

    Summary
    Although there was an interaction of sleep pathology and age, a regression analysis yielded clear evidence that the effects of DSIP were correlated to the degree of sleep disturbance.
    2 context sentences
    Summary · context
    The immediate effects of one week of Delta Sleep-Inducing Peptide (DSIP) administration (6 X 30 nmol/kg b.w., i.v.) and late effects after a follow-up period of one week were investigated in a sleep laboratory study.
    Summary · context
    The population of 18 chronic psychophysiological insomniacs was subdivided into two groups of middle-aged (29-59) and older (60-83) insomniacs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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