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Study · Animal study (in vivo) · rat · 1986

3 results

Delta sleep-inducing peptide in spontaneously hypertensive rats.

Graf MV, Kastin AJ, Schoenenberger GA

Pharmacology, biochemistry, and behavior1 Jun 1986Cited by 8 (Europe PMC)

PMID3755534 (opens in a new tab)DOI10.1016/0091-3057(86)90524-1 (opens in a new tab)PepBankPUB-03755534
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In spontaneously hypertensive rats, DSIP infusion maintained blood pressure at about 200 mm Hg, while it rose significantly to about 220 mm Hg in saline-infused controls.

    In plain wordsIn rats with high blood pressure, DSIP infusion kept blood pressure steady, while it rose in saline-infused rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseBlood pressure during 10-day DSIP infusion
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    0.9% NaCl infusion
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    200 micrograms/kg/day · osmotic minipump infusion · 10 daysAs given in this study (rat).

    Measurements

    Blood pressure
    ≈ 200 mm Hg
    DSIP infusion, day 10
    Blood pressure
    ≈ 220 mm Hg
    NaCl controls, day 10

    Source sentences

    Summary
    This resulted in in maintenance of BP at a level of about 200 mm Hg as compared with the significant increase to about 220 mm Hg after 10 days in the SHR controls infused with 0.9% NaCl.
    1 context sentence
    Summary · context
    DSIP was then infused for 10 days by osmotic minipump (200 micrograms/kg/day) into SHR.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In spontaneously hypertensive rats, daily subcutaneous DSIP injection for 5 days gave findings similar to those of the 10-day infusion.

    In plain wordsIn rats with high blood pressure, daily DSIP injections for 5 days gave results similar to the infusion.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseBlood pressure after daily DSIP injection
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    200 micrograms/kg daily · subcutaneous · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    After daily SC injection of a single dose of 200 micrograms/kg DSIP for each of 5 days in SHR, findings were similar.
    1 context sentence
    Summary · context
    This resulted in in maintenance of BP at a level of about 200 mm Hg as compared with the significant increase to about 220 mm Hg after 10 days in the SHR controls infused with 0.9% NaCl.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In spontaneously hypertensive rats, plasma DSIP-like immunoreactivity was about 25% higher than in normotensive Wistar-Kyoto controls.

    In plain wordsIn rats, the body's own DSIP-like material in blood was higher in rats with high blood pressure than in normal rats.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePlasma DSIP-like immunoreactivity in SHR versus WK controls
    Study

    ratn: not reported in source

    spontaneously hypertensive rats (SHR)
    Comparator
    Normotensive Wistar-Kyoto controls
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Measurements

    DSIP-like immunoreactivity difference
    ≈ 25%
    SHR versus WK plasma

    Source sentences

    Summary
    They were found to be about 25% higher in SHR plasma than in the plasma of the normotensive Wistar-Kyoto (WK) controls.
    1 context sentence
    Summary · context
    In this study, the concentrations of DSIP-like immunoreactivity were measured by radioimmunoassay in the plasma of spontaneously hypertensive rats (SHR).

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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