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Study · Animal study (in vivo) · mouse and rat · 1988

5 results

Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).

Nakamura A, Nakashima M, Sugao T, Kanemoto H, Fukumura Y, Shiomi H

European journal of pharmacology1 Oct 1988Cited by 8 (Europe PMC)

PMID2853064 (opens in a new tab)DOI10.1016/0014-2999(88)90510-9 (opens in a new tab)PepBankPUB-02853064
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, DSIP given intracerebroventricularly or intracisternally produced a significant dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests.

    In plain wordsIn mice, DSIP injected into the brain fluid reduced pain responses, and a higher dose had a greater effect.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntinociception after central DSIP (tail-pinch and hot-plate tests)
    Study

    mousen: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular or intracisternalAs given in this study (mouse).

    Source sentences

    Summary
    DSIP, administered intracerebroventricularly or intracisternally to mice, produced a significant dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests.
    1 context sentence
    Summary · context
    The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal DSIP did not produce an antinociceptive effect.

    In plain wordsIn mice, DSIP injected into the spinal canal did not reduce pain responses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAntinociception after intrathecal DSIP
    Study

    mousen: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    Intrathecal administration of DSIP did not produce such an effect.
    1 context sentence
    Summary · context
    The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, pretreatment with the opioid antagonist naloxone blocked the antinociceptive effect of DSIP.

    In plain wordsIn mice, the opioid blocker naloxone stopped the pain-relieving effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP antinociception after naloxone
    Study

    mousen: not reported in source

    Comparator
    No naloxone pretreatment
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist, naloxone.
    1 context sentence
    Summary · context
    The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In morphine-tolerant mice, DSIP did not produce an antinociceptive effect.

    In plain wordsIn mice that had become tolerant to morphine, DSIP did not reduce pain responses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAntinociception of DSIP in morphine-tolerant mice
    Study

    mousen: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, DSIP did not produce an antinociceptive effect in morphine-tolerant mice.
    1 context sentence
    Summary · context
    The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, DSIP produced antinociceptive effects similar to those in mice.

    In plain wordsIn rats, DSIP reduced pain responses in a way similar to mice.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseAntinociception after central DSIP in rats
    Study

    ratn: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar antinociceptive effects of DSIP were observed in rats.
    1 context sentence
    Summary · context
    The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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