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Study · Animal study (in vivo) · rabbit · 1987

4 results

[Parasympathetic regulation of cardiac rhythm in delta sleep-inducing peptide deficiency].

Zviagintseva MA, Kosharskaia IL, Badikov VI, Beskrovnova NN, Ul'ianinskiĭ LS

Biulleten' eksperimental'noi biologii i meditsiny1 Jul 1987

PMID3620643 (opens in a new tab)PepBankPUB-03620643
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rabbits, administration of delta-sleep peptide caused practically no damage of the myocardial ultrastructure.

    In plain wordsIn rabbits, giving DSIP caused almost no damage to the fine structure of heart muscle.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMyocardial ultrastructure damage after DSP administration
    Study

    rabbitn: not reported in source

    Outcome group
    Adverse events · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Antiserum, like DSP, administration causes practically no damage of the myocardial ultrastructure.
    1 context sentence
    Summary · context
    The effect of delta-sleep peptide (DSP) deficiency on the parasympathetic regulation of the heart rate was studied on 35 rabbits.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, injection of antiserum against delta-sleep peptide, which causes deficiency of the peptide, increased heart rate in freely behaving animals.

    In plain wordsIn rabbits, removing the body's own DSIP with antiserum raised heart rate in freely moving animals.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseHeart rate in freely behaving animals after antiserum against DSIP
    Study

    rabbitn: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    heart rate increase in freely behaving animals
    1 context sentence
    Summary · context
    The effect of delta-sleep peptide (DSP) deficiency on the parasympathetic regulation of the heart rate was studied on 35 rabbits.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In rabbits, injection of antiserum against delta-sleep peptide decreased the negative chronotropic effect of direct vagus irritation.

    In plain wordsIn rabbits, removing the body's own DSIP with antiserum weakened the heart-slowing effect of vagus nerve stimulation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNegative chronotropic effect on direct vagus irritation after antiserum against DSIP
    Study

    rabbitn: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    a decrease in negative chronotropic effect with direct vagus irritation.
    1 context sentence
    Summary · context
    The effect of delta-sleep peptide (DSP) deficiency on the parasympathetic regulation of the heart rate was studied on 35 rabbits.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 04AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Safety outcome

    In rabbits, antiserum against delta-sleep peptide caused practically no damage of the myocardial ultrastructure.

    In plain wordsIn rabbits, antiserum against DSIP caused almost no damage to the fine structure of heart muscle.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMyocardial ultrastructure damage after antiserum against DSIP
    Study

    rabbitn: not reported in source

    Outcome group
    Adverse events · Cardiovascular

    Source sentences

    Summary
    Antiserum, like DSP, administration causes practically no damage of the myocardial ultrastructure.
    1 context sentence
    Summary · context
    The effect of delta-sleep peptide (DSP) deficiency on the parasympathetic regulation of the heart rate was studied on 35 rabbits.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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