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Study · Animal study (in vivo) · rat · 2016

14 results

Effect of Delta Sleep-Inducing Peptide on Functional State of Hepatocytes in Rats During Restraint Stress.

Bobyntsev II, Kryukov AA, Belykh AE, Dudka VT

Bulletin of experimental biology and medicine23 Feb 2016

PMID26902351 (opens in a new tab)DOI10.1007/s10517-016-3186-8 (opens in a new tab)PepBankPUB-26902351
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats under acute restraint stress, DSIP at 40 µg/kg increased liver catalase activity.

    In plain wordsIn rats under short-term stress, DSIP at 40 µg/kg raised catalase activity in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver catalase activity, acute stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Treatment with the peptide in a dose of 40 μg/kg increased catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of animals subjected to acute stress.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats under acute restraint stress, DSIP at 40 µg/kg increased liver SOD activity.

    In plain wordsIn rats under short-term stress, DSIP at 40 µg/kg raised SOD activity in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver SOD activity, acute stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Treatment with the peptide in a dose of 40 μg/kg increased catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of animals subjected to acute stress.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats under acute restraint stress, DSIP at 40 µg/kg increased liver MDA concentration.

    In plain wordsIn rats under short-term stress, DSIP at 40 µg/kg raised MDA concentration in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseLiver MDA concentration, acute stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Treatment with the peptide in a dose of 40 μg/kg increased catalase and superoxide dismutase (SOD) activities and malonic dialdehyde (MDA) concentration in the liver homogenate of animals subjected to acute stress.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats under acute restraint stress, DSIP at the other doses (120 and 360 µg/kg) caused no significant change in the liver markers.

    In plain wordsIn rats under short-term stress, DSIP at the two higher doses did not significantly change the liver markers.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeLiver oxidation markers at other doses, acute stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    120 and 360 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    No significant changes were found after administration of this peptide in other doses.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats under chronic restraint stress, DSIP at 40 µg/kg decreased liver catalase activity.

    In plain wordsIn rats under long-term stress, DSIP at 40 µg/kg lowered catalase activity in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver catalase activity, chronic stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Under conditions of chronic stress, the peptide in a dose of 40 μg/kg caused the most pronounced effect. Catalase and SOD activities and MDA concentration decreased, while aminotransferase activity and protein content remained unchanged under these conditions.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats under chronic restraint stress, DSIP at 40 µg/kg decreased liver SOD activity.

    In plain wordsIn rats under long-term stress, DSIP at 40 µg/kg lowered SOD activity in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver SOD activity, chronic stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Under conditions of chronic stress, the peptide in a dose of 40 μg/kg caused the most pronounced effect. Catalase and SOD activities and MDA concentration decreased, while aminotransferase activity and protein content remained unchanged under these conditions.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats under chronic restraint stress, DSIP at 40 µg/kg decreased liver MDA concentration.

    In plain wordsIn rats under long-term stress, DSIP at 40 µg/kg lowered MDA concentration in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver MDA concentration, chronic stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Under conditions of chronic stress, the peptide in a dose of 40 μg/kg caused the most pronounced effect. Catalase and SOD activities and MDA concentration decreased, while aminotransferase activity and protein content remained unchanged under these conditions.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic restraint stress, DSIP at 40 µg/kg did not change aminotransferase activity.

    In plain wordsIn rats under long-term stress, DSIP at 40 µg/kg did not change liver enzyme activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAminotransferase activity, chronic stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Under conditions of chronic stress, the peptide in a dose of 40 μg/kg caused the most pronounced effect. Catalase and SOD activities and MDA concentration decreased, while aminotransferase activity and protein content remained unchanged under these conditions.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic restraint stress, DSIP at 40 µg/kg did not change total serum protein content.

    In plain wordsIn rats under long-term stress, DSIP at 40 µg/kg did not change blood protein content.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeTotal serum protein, chronic stress
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    40 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Under conditions of chronic stress, the peptide in a dose of 40 μg/kg caused the most pronounced effect. Catalase and SOD activities and MDA concentration decreased, while aminotransferase activity and protein content remained unchanged under these conditions.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats under restraint stress, DSIP at 120 µg/kg decreased liver SOD activity.

    In plain wordsIn stressed rats, DSIP at 120 µg/kg lowered SOD activity in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver SOD activity at 120 µg/kg
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    120 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Administration of the peptide in a dose of 120 μg/kg was accompanied by a decrease in SOD activity and MDA concentration, increase in total protein content, and reduction of AST activity.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats under restraint stress, DSIP at 120 µg/kg decreased liver MDA concentration.

    In plain wordsIn stressed rats, DSIP at 120 µg/kg lowered MDA concentration in the liver.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseLiver MDA concentration at 120 µg/kg
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    120 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Administration of the peptide in a dose of 120 μg/kg was accompanied by a decrease in SOD activity and MDA concentration, increase in total protein content, and reduction of AST activity.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats under restraint stress, DSIP at 120 µg/kg increased total protein content.

    In plain wordsIn stressed rats, DSIP at 120 µg/kg raised total protein content.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseTotal serum protein at 120 µg/kg
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    120 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Administration of the peptide in a dose of 120 μg/kg was accompanied by a decrease in SOD activity and MDA concentration, increase in total protein content, and reduction of AST activity.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rats under restraint stress, DSIP at 120 µg/kg reduced AST activity.

    In plain wordsIn stressed rats, DSIP at 120 µg/kg lowered the liver enzyme AST.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAST activity at 120 µg/kg
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    120 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Administration of the peptide in a dose of 120 μg/kg was accompanied by a decrease in SOD activity and MDA concentration, increase in total protein content, and reduction of AST activity.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In rats under restraint stress, raising the DSIP dose to 360 µg/kg abolished its effects.

    In plain wordsIn stressed rats, raising the DSIP dose to 360 µg/kg removed the effects seen at lower doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeEffects at 360 µg/kg
    Study

    ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    360 µg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Increasing the peptide dose to 360 μg/kg abolished its effects.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide (40, 120, and 360 μg/kg intraperitoneally, 1 h before the experiment) on free radical oxidation in the liver, aminotransferase activity, and total serum protein content in male Wistar rats during restraint stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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