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Study · Ex vivo tissue · rat · 1992

3 results

In vitro effects of putative neurotransmitters on synaptic ribbon numbers and N-acetyltransferase activity in the rat pineal gland.

Gupta BB, Seidel A, Spessert R, Büttner W, Klauke N, Spanier J, Weber A, Ziemer D, Vollrath L

Journal of neural transmission. General section1 Jan 1992Cited by 8 (Europe PMC)

PMID1356354 (opens in a new tab)DOI10.1007/bf01250669 (opens in a new tab)PepBankPUB-01356354
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In rat pineal glands in vitro, DSIP significantly increased NAT activity, a marker of melatonin synthesis.

    In plain wordsIn rat pineal tissue in the lab, DSIP raised NAT activity, a marker of melatonin production.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePineal serotonin N-acetyltransferase (NAT) activity
    Study

    ratn: not reported in source

    rat pineal gland in vitro
    Comparator
    Control
    Outcome group
    Sleep · Endocrine and hormones
    Studied dose
    Dose not stated · in vitroAs given in this study (rat).

    Source sentences

    Summary
    Norepinephrine (NE), Delta sleep-inducing peptide (DSIP), vasoactive intestinal polypeptide (VIP), adenosine and N-acetyl-asp-glu (NAAG) significantly increased NAT activity in rat pineal.
    2 context sentences
    Summary · context
    NAT activity was used to monitor melatonin synthesis under the experimental conditions used.
    Summary · context
    In the present study, we have investigated in vitro effects of a number of classical neurotransmitters and neuropeptides.
  2. 02LabEx vivo tissueEfficacy outcome

    In rat pineal glands in vitro, DSIP increased the stimulatory effect of norepinephrine on NAT activity.

    In plain wordsIn rat pineal tissue in the lab, DSIP made the NAT-raising effect of norepinephrine stronger.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNAT activity with norepinephrine plus DSIP
    Study

    ratn: not reported in source

    rat pineal gland in vitro
    Comparator
    Norepinephrine alone
    Outcome group
    Sleep · Endocrine and hormones
    Studied dose
    Dose not stated · in vitroAs given in this study (rat).

    Source sentences

    Summary
    DSIP and VIP also increase the stimulatory effect of NE on NAT activity.
    1 context sentence
    Summary · context
    In the present study, we have investigated in vitro effects of a number of classical neurotransmitters and neuropeptides.
  3. 03LabEx vivo tissueEfficacy outcome

    In rat pineal glands in vitro, DSIP had no effect on synaptic ribbon numbers.

    In plain wordsIn rat pineal tissue in the lab, DSIP did not change the number of synaptic ribbons.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSynaptic ribbon numbers
    Study

    ratn: not reported in source

    rat pineal gland in vitro
    Comparator
    Control
    Outcome group
    Circadian rhythm · Nervous system and cognition
    Studied dose
    Dose not stated · in vitroAs given in this study (rat).

    Source sentences

    Summary
    These neurochemicals had no effect on SR numbers.
    1 context sentence
    Summary · context
    In the present study, we have investigated in vitro effects of a number of classical neurotransmitters and neuropeptides.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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