In primary rat astroglial cultures, DSIP did not stimulate release of prostaglandin D2 into the medium, unlike MDP, LPS and IL-1.
In plain wordsIn cells from rat brain, DSIP did not make the cells release PGD2, unlike three other sleep-linked substances.
- Outcome
- No significant changePGD2 release from astrocytes
- Study
ratn: not reported in source
Primary rat brain astroglial cell cultures- Outcome group
- Inflammation markers · Nervous system and cognition
- Studied dose
- Dose not stated
Source sentences
A large amount of PGD2 was released into the culture medium by stimulation with MDP, LPS, and IL-1 but DSIP and uridine failed to stimulate such release.
1 context sentence(design, population, supporting numbers)
We used primary cultures of rat brain astroglial cells in order to investigate the interrelationship between PGD2 and other sleep-promoting substances such as muramyl dipeptide (MDP), lipopolysaccharide (LPS), delta-sleep-inducing peptide (DSIP), uridine, and interleukin 1 (IL-1).