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Study · Animal study (in vivo) · rat · 1981

3 results

Permeability of blood-brain barrier to DSIP peptides.

Kastin AJ, Nissen C, Coy DH

Pharmacology, biochemistry, and behavior1 Dec 1981Cited by 31 (Europe PMC)

PMID6895670 (opens in a new tab)DOI10.1016/0091-3057(81)90061-7 (opens in a new tab)PepBankPUB-06895670
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, a significant increase in brain DSIP-like immunoreactivity was found in one part of the study after peripheral DSIP injection, indicating some peptide crossed the blood-brain barrier.

    In plain wordsIn rats, injected DSIP led to higher DSIP-like levels in the brain in part of the study, so some peptide crossed into the brain.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBrain DSIP-like immunoreactivity after peripheral DSIP injection
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    A significant increase in DSIP-like immunoreactivity found in rat brain in one part of the study after peripheral injection of DSIP indicated, therefore, that some peptide crossed the BBB.
    1 context sentence
    Summary · context
    An improved radioimmunoassay (RIA) for delta sleep-inducing peptide (DSIP) was used to study the permeability of the blood-brain barrier (BBB) to DSIP peptides.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, brain tissue levels were much higher after intracarotid [D-Ala3]-DSIP than after DSIP, so non-specific leakage was unlikely to be the only explanation.

    In plain wordsIn rats, an analog of DSIP reached the brain at much higher levels than DSIP itself, so simple leakage is an unlikely sole cause.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBrain levels after intracarotid [D-Ala3]-DSIP versus DSIP
    Study

    ratn: not reported in source

    Comparator
    DSIP
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intracarotidAs given in this study (rat).

    Source sentences

    Summary
    The much higher levels found in brain tissue after intracarotid administration of [D-Ala3]-DSIP as compared with DSIP made it unlikely that non-specific leakage of peptide across the BBB was the only explanation.
    1 context sentence
    Summary · context
    An improved radioimmunoassay (RIA) for delta sleep-inducing peptide (DSIP) was used to study the permeability of the blood-brain barrier (BBB) to DSIP peptides.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 03LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Other

    In the radioimmunoassay, [D-Ala3]-DSIP reacted fully, and at least 8 of the 9 amino acids of natural DSIP were needed for antibody recognition.

    In plain wordsIn lab tests, the assay antibody needed at least 8 of the 9 amino acids of DSIP to detect it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableAntibody recognition requirement of the DSIP radioimmunoassay
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Amino acids required for recognition
    ≥ 8 of 9 amino acids
    RIA antibody

    Source sentences

    Summary
    Although the synthetic analog [D-Ala3]-DSIP reacts fully in the assay, at least 8 of the 9 amino acids of the naturally occurring DSIP sequence are required for recognition by the antibody.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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