Skip to content

Study · Animal study (in vivo) · 1994

2 results

Is the nucleus raphe dorsalis a target for the peptides possessing hypnogenic properties?

el Kafi B, Cespuglio R, Leger L, Marinesco S, Jouvet M

Brain research1 Feb 1994Cited by 32 (Europe PMC)

PMID8180798 (opens in a new tab)DOI10.1016/0006-8993(94)91235-1 (opens in a new tab)PepBankPUB-08180798
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals, DSIP injected into the nucleus raphe dorsalis produced no sleep effect at any dose or injection site.

    In plain wordsIn animals, DSIP injected into one brain area (the dorsal raphe) had no effect on sleep at any dose tried.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep after DSIP injection into nucleus raphe dorsalis
    Study

    n: not reported in source

    Injection into the nucleus raphe dorsalis
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated · injection into the nucleus raphe dorsalisAs given in this study.

    Source sentences

    Summary
    With DSIP, no sleep effect was found whatever the dose used or the site injected
    1 context sentence
    Summary · context
    In the present work, 3 hypnogenic substances, CLIP (corticotropin-Like intermediate lobe peptide), VIP (vasoactive intestinal polypeptide) and DSIP (delta sleep inducing peptide), were injected into the nRD in order to determine whether these compounds still induce sleep by local administration.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In animals, no DSIP-immunoreactive fibers were located in the nucleus raphe dorsalis.

    In plain wordsIn animals, no fibers containing the body's own DSIP were found in the dorsal raphe brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeDSIP-immunoreactive fibers in nucleus raphe dorsalis
    Study

    n: not reported in source

    Injection into the nucleus raphe dorsalis
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    in the same manner, no DSIP-IR fibers have been located in this structure.
    1 context sentence
    Summary · context
    In the present work, 3 hypnogenic substances, CLIP (corticotropin-Like intermediate lobe peptide), VIP (vasoactive intestinal polypeptide) and DSIP (delta sleep inducing peptide), were injected into the nRD in order to determine whether these compounds still induce sleep by local administration.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.