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Study · Animal study (in vivo) · rat · 1980

6 results

Effect of delta sleep inducing peptide (DSIP) and arginine vasotocin (AVT) on sleep and motor activity in the rat.

Tobler I, Borbély AA

Waking and sleeping1 Apr 1980Cited by 21 (Europe PMC)

PMID7405185 (opens in a new tab)PepBankPUB-07405185
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, motor activity was not significantly reduced during the 24 h after systemic DSIP.

    In plain wordsIn rats, DSIP given by injection did not significantly reduce movement over the next 24 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeMotor activity in the 24 h after systemic DSIP
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    40-160 nmol/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Motor activity was not significantly reduced during the 24 h following systemic DSIP administration (40-160 nmol/kg i.p.)
    1 context sentence
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, sleep was not significantly increased in the 2 hours after DSIP injection or infusion into the lateral or third ventricle.

    In plain wordsIn rats, DSIP placed in the brain ventricles did not significantly increase sleep in the next 2 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep after DSIP injection or infusion into the ventricle
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    7-24 nmol · intracerebroventricular (lateral or third ventricle)As given in this study (rat).

    Source sentences

    Summary
    nor were sleep and the power of the EEG delta-band significantly increased in the 2 hours following injection or infusion of DSIP into the lateral or third ventricle (7-24 nmol)
    1 context sentence
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, EEG delta-band power was not significantly increased in the 2 hours after DSIP injection or infusion into the lateral or third ventricle.

    In plain wordsIn rats, DSIP placed in the brain ventricles did not significantly raise slow-wave brain activity in the next 2 hours.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeEEG delta-band power after DSIP injection or infusion into the ventricle
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    7-24 nmol · intracerebroventricular (lateral or third ventricle)As given in this study (rat).

    Source sentences

    Summary
    nor were sleep and the power of the EEG delta-band significantly increased in the 2 hours following injection or infusion of DSIP into the lateral or third ventricle (7-24 nmol)
    1 context sentence
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, dark-time motor activity was reduced 1 and 2 days after DSIP at 160 nmol/kg.

    In plain wordsIn rats, DSIP reduced movement during the dark period 1 and 2 days after a high dose.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDark-time motor activity 1 and 2 days after DSIP
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    160 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    Dark-time motor activity was reduced 1 and 2 days after DSIP administration (160 nmol/kg)
    1 context sentence
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, motor activity in the first 4 h after DSIP at 80 nmol/kg was increased.

    In plain wordsIn rats, movement in the first 4 hours after a mid dose of DSIP went up.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMotor activity in the first 4 h after DSIP
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    80 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    the activity in the first 4 h after injection (80 nmol/kg) was increased.
    1 context sentence
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, EEG delta-band power was reduced after DSIP at 7 nmol given into the third ventricle.

    In plain wordsIn rats, DSIP placed in the third brain ventricle reduced slow-wave brain activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseEEG delta-band power after third-ventricle DSIP
    Study

    ratn: not reported in source

    rat in vivo
    Outcome group
    Sleep · Sleep
    Studied dose
    7 nmol · intracerebroventricular (third ventricle)As given in this study (rat).

    Source sentences

    Summary
    the power in the delta-band was reduced after administration of DISP (7 nmol)
    2 context sentences
    Summary · context
    into the third ventricle.
    Summary · context
    The effect of Delta Sleep Inducing Peptide (DSIP) and arginine vasotocin (AVT) on motor activity and sleep was investigated in the rat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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