Skip to content

Study · Animal study (in vivo) · rat and mouse · 1988

5 results

[The effect of delta sleep-inducing peptide on the convulsive activity in corasol kindling].

Shandra AA, Godlevskiĭ LS, Kryzhanovskiĭ GN, Makul'kin RF, Mikhaleva II

Biulleten' eksperimental'noi biologii i meditsiny1 Sept 1988Cited by 2 (Europe PMC)

PMID3167173 (opens in a new tab)PepBankPUB-03167173
Publisher pageAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats and mice with corasole kindling, DSIP injection delayed the manifestation of generalized seizures.

    In plain wordsIn rats and mice with induced kindling seizures, DSIP delayed the start of generalized seizures.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseOnset of generalized seizures during kindling
    Study

    rat, mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat, mouse).

    Source sentences

    Summary
    DSIP injection delayed the manifestation of generalized seizures during kindling
    2 context sentences
    Summary · context
    The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice.
    Summary · context
    The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats and mice with corasole kindling, DSIP injection suppressed seizure activity.

    In plain wordsIn rats and mice with induced kindling seizures, DSIP reduced seizure activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizure activity during kindling
    Study

    rat, mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat, mouse).

    Source sentences

    Summary
    led to the suppression of seizure activity
    2 context sentences
    Summary · context
    The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice.
    Summary · context
    The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats and mice with corasole kindling, DSIP injection reduced the mortality rate of animals that developed kindled seizures.

    In plain wordsIn rats and mice with induced kindling seizures, DSIP lowered the death rate of animals that developed seizures.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseMortality of animals with kindled seizures
    Study

    rat, mousen: not reported in source

    Outcome group
    Mortality · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat, mouse).

    Source sentences

    Summary
    reduced the mortality rate of animals that developed kindled seizures.
    2 context sentences
    Summary · context
    The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice.
    Summary · context
    The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats and mice with corasole kindling, the antiepileptic effect of DSIP was observed from 5 minutes to 24 hours after the injection.

    In plain wordsIn rats and mice with induced kindling seizures, the anti-seizure effect of DSIP was seen from 5 minutes to 24 hours after injection.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableTime window of the antiepileptic effect
    Study

    rat, mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat, mouse).

    Source sentences

    Summary
    The antiepileptic effect of DSIP was observed throughout the period of 5 minutes to 24 hours after the injection.
    2 context sentences
    Summary · context
    The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice.
    Summary · context
    The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats and mice with corasole kindling, naloxone did not change the antiepileptic effect of DSIP.

    In plain wordsIn rats and mice with induced kindling seizures, naloxone did not change the anti-seizure effect of DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeAntiepileptic effect of DSIP with naloxone
    Study

    rat, mousen: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 micrograms/kg · intraperitonealAs given in this study (rat, mouse).

    Source sentences

    Summary
    Naloxone (2.5 mg/kg) did not change the antiepileptic effect of DSIP.
    2 context sentences
    Summary · context
    The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice.
    Summary · context
    The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.