Skip to content

Study · Animal study (in vivo) · rat · 1987

5 results

Delta sleep-inducing peptide (DSIP) stimulates growth hormone (GH) release in the rat by hypothalamic and pituitary actions.

Iyer KS, McCann SM

Peptides1 Jan 1987Cited by 18 (Europe PMC)

PMID3575154 (opens in a new tab)DOI10.1016/0196-9781(87)90163-x (opens in a new tab)PepBankPUB-03575154
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious ovariectomized rats, intraventricular DSIP raised plasma GH from 30 min onward, for the 120 min of the experiment, while diluent did not.

    In plain wordsIn rats, DSIP given into the brain raised growth hormone in blood, while the diluent did not.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePlasma GH after intraventricular DSIP (5 micrograms)
    Study

    ratn: not reported in source

    Conscious ovariectomized rats with third ventricular cannulae
    Comparator
    Diluent
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 micrograms · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    In the initial experiment, intraventricular injection of 5 micrograms of the peptide induced an elevation of GH which became significant by 30 min and persisted for the 120 min duration of the experiment after the injection. Diluent-injected animals showed a slight initial drop in GH and then no increase.
    1 context sentence
    Summary · context
    To evaluate possible effects of delta sleep-inducing peptide on GH release, the peptide was micro-injected into conscious animals with third ventricular cannulae and blood samples were drawn from indwelling external jugular vein cannulae. Ovariectomized animals were used in order to eliminate gonadal steroid feedback.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious ovariectomized rats, the GH rise after DSIP was dose-related, with a minimal effective dose of 0.1 microgram and a linear log-dose increase up to 10 micrograms.

    In plain wordsIn rats, higher doses of DSIP given into the brain raised growth hormone more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDose-response of plasma GH to DSIP
    Study

    ratn: not reported in source

    Conscious ovariectomized rats with third ventricular cannulae
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.1-10 micrograms · intraventricularAs given in this study (rat).

    Measurements

    Minimal effective dose
    0.1 microgram
    plasma GH

    Source sentences

    Summary
    The increase in plasma GH induced by the peptide was dose-related with a minimal effective dose of 0.1 microgram and a linear log-dose increase to a dose of 10 micrograms.
    1 context sentence
    Summary · context
    To evaluate possible effects of delta sleep-inducing peptide on GH release, the peptide was micro-injected into conscious animals with third ventricular cannulae and blood samples were drawn from indwelling external jugular vein cannulae. Ovariectomized animals were used in order to eliminate gonadal steroid feedback.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, pretreatment with the dopamine receptor blocker pimozide blocked the GH rise caused by DSIP.

    In plain wordsIn rats, a drug that blocks dopamine receptors stopped the growth hormone rise caused by DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBlockade of DSIP-induced GH rise by pimozide
    Study

    ratn: not reported in source

    Conscious ovariectomized rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · intraventricularAs given in this study (rat).

    Source sentences

    Summary
    This effect is presumably mediated hypothalamically via a dopaminergic mechanism since it could be blocked by pre-treatment of the animals with pimozide, a dopamine receptor blocker.
    1 context sentence
    Summary · context
    To evaluate possible effects of delta sleep-inducing peptide on GH release, the peptide was micro-injected into conscious animals with third ventricular cannulae and blood samples were drawn from indwelling external jugular vein cannulae. Ovariectomized animals were used in order to eliminate gonadal steroid feedback.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured rat pituitary cells, DSIP increased GH release in a dose-related manner, starting at the lowest dose tested and peaking at 10(-10) M, about 50% above basal values.

    In plain wordsIn rat pituitary cells in a dish, DSIP raised growth hormone release with rising dose, up to about 50% above basal.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGH release from cultured pituitary cells
    Study

    ratn: not reported in source

    Dispersed overnight cultured pituitary cells from ovariectomized rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-12) to 10(-10) MAs given in this study (rat).

    Measurements

    GH release increase at best dose
    ≈ 50%
    above basal

    Source sentences

    Summary
    Dispersed overnight, cultured pituitary cells from ovariectomized rats exhibited a dose-related increase in GH release in static incubations with DSIP. A response occurred with the lowest dose tested (10(-12) M) which increased to a maximum at 10(-10) M DSIP.
    1 context sentence
    Summary · context
    The increase even at the most effective dose was approximately 50% above the basal values.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured rat pituitary cells, the GH response declined at higher DSIP doses and was no longer significant at 10(-7) and 10(-5) M.

    In plain wordsIn rat pituitary cells in a dish, the growth hormone response to DSIP faded at the highest doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeGH release from pituitary cells at high DSIP doses
    Study

    ratn: not reported in source

    Dispersed overnight cultured pituitary cells from ovariectomized rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-7) to 10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    The responses then declined at higher doses such that they were no longer significant at doses of 10(-7) and 10(-5) M.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.