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Study · Animal study (in vivo) · rat · 1980

10 results

Thermoregulatory and locomotor effects of DSIP: paradoxical interaction with d-amphetamine.

Yehuda S, Kastin AJ, Coy DH

Pharmacology, biochemistry, and behavior1 Dec 1980Cited by 32 (Europe PMC)

PMID6894196 (opens in a new tab)DOI10.1016/0091-3057(80)90225-7 (opens in a new tab)PepBankPUB-06894196
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats kept at 4 degrees C, a low peripheral dose of DSIP caused hypothermia.

    In plain wordsIn rats kept in the cold, a low dose of DSIP lowered body temperature.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseBody temperature at 4 degrees C, 0.1 mg/kg
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    0.1 mg/kg · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    A low dose (0.1 mg/kg) of peripherally administered delta sleep-inducing peptide (DSIP) caused hypothermia in rats maintained at 4 degrees C
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats kept at 4 degrees C, larger peripheral DSIP doses did not cause hypothermia.

    In plain wordsIn rats kept in the cold, larger doses of DSIP did not lower body temperature.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeBody temperature at 4 degrees C, 1.0 and 3.0 mg/kg
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    1.0 and 3.0 mg/kg · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    but larger doses (1.0 or 3.0 mg/kg) did not.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 22 degrees C, all 3 doses of DSIP caused hyperthermia.

    In plain wordsIn rats at room temperature, all three doses of DSIP raised body temperature.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseBody temperature at 22 degrees C
    Study

    ratn: not reported in source

    Outcome group
    Body temperature · Whole body
    Studied dose
    0.1, 1.0 and 3.0 mg/kg · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    At 22 degrees C all 3 doses of DSIP caused hyperthermia.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 4 degrees C, DSIP had no effect on d-amphetamine-induced hypothermia.

    In plain wordsIn cold rats, DSIP did not change the body-temperature drop caused by d-amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changed-Amphetamine-induced hypothermia at 4 degrees C
    Study

    ratn: not reported in source

    Comparator
    d-Amphetamine alone
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    at 4 degrees C DSIP had no effect on d-amphetamine-induced hypothermia, but at 22 degrees C DSIP reversed the usual d-amphetamine-induced effect of hyperthermia to hypothermia.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 22 degrees C, DSIP reversed the usual d-amphetamine-induced hyperthermia to hypothermia.

    In plain wordsIn rats at room temperature, DSIP turned the usual d-amphetamine temperature rise into a temperature drop.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Decreased-Amphetamine-induced hyperthermia at 22 degrees C
    Study

    ratn: not reported in source

    Comparator
    d-Amphetamine alone
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    at 22 degrees C DSIP reversed the usual d-amphetamine-induced effect of hyperthermia to hypothermia.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 4 degrees C, DSIP potentiated the hypermotility effects of d-amphetamine.

    In plain wordsIn cold rats, DSIP increased the extra movement caused by d-amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Increased-Amphetamine hypermotility at 4 degrees C
    Study

    ratn: not reported in source

    Comparator
    d-Amphetamine alone
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    At 4 degrees C, DSIP also potentiated the hypermotility effects of d-amphetamine but blocked it at 22 degrees C.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 22 degrees C, DSIP blocked the hypermotility effects of d-amphetamine.

    In plain wordsIn rats at room temperature, DSIP blocked the extra movement caused by d-amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Decreased-Amphetamine hypermotility at 22 degrees C
    Study

    ratn: not reported in source

    Comparator
    d-Amphetamine alone
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    but blocked it at 22 degrees C.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats at 22 degrees C, many animals given DSIP with d-amphetamine paradoxically showed what appeared to be sleep.

    In plain wordsIn rats at room temperature, many animals given DSIP and d-amphetamine seemed to fall asleep.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep-like state with DSIP 0.1 mg/kg plus d-amphetamine 15.0 mg/kg at 22 degrees C
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    0.1 mg/kg · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    Many rats receiving DSIP (0.1 mg/kg) and d-amphetamine (15.0 mg/kg) at 22 degrees C paradoxically exhibited what appeared to be sleep.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the sleep-like effect was not found after several other doses of DSIP and d-amphetamine, after chlorpromazine, or at a cold ambient temperature.

    In plain wordsIn rats, the sleep-like effect did not appear with other doses, with chlorpromazine, or in the cold.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeSleep-like state after other DSIP and d-amphetamine doses, chlorpromazine or cold
    Study

    ratn: not reported in source

    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    This sleep-like effect was not found after several other doses of DSIP and d-amphetamine, chlorpromazine, or at a cold ambient temperature.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, sodium methohexital caused apparent sleep in animals given DSIP alone or with d-amphetamine, but not in rats given d-amphetamine alone.

    In plain wordsIn rats, a sedative produced apparent sleep in animals given DSIP, but not in animals given d-amphetamine alone.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSodium methohexital-induced apparent sleep
    Study

    ratn: not reported in source

    Comparator
    d-Amphetamine alone
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated · peripheral injectionAs given in this study (rat).

    Source sentences

    Summary
    Sodium methohexital caused apparent sleep in animals treated with DSIP alone or with DSIP and d-amphetamine, but was unable to induce this effect in rats receiving d-amphetamine alone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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