[The physiological properties of endogenous oligopeptides that enhance resistance to emotional stress].

Iumatov EA, Salieva RM

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Mar 1993

PMID7686317PepBankPUB-07686317

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In August rats, hypothalamic substance P increased 3 h and 6 h after intraperitoneal DSIP at 60 and 120 nM/kg.
In plain wordsIn rats prone to stress, DSIP raised substance P in the brain 3 and 6 hours after injection.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P after single i.p. DSIP
Study
ratn: not reported in source
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The hypothalamic SP level increased 3 h and 6 h after systemic i. p. DSIP administration in doses of 60 and 120 nM/kg.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631701
02AnimalAnimal study (in vivo)Mechanism
In August rats exposed to stress, five DSIP administrations before stress strongly increased hypothalamic substance P.
In plain wordsIn rats exposed to stress, five DSIP doses before stress strongly raised substance P in the brain.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P after five DSIP doses before stress
Study
ratn: not reported in source
aggressive-conflict stress
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Quintuple DSIP administration in the above mentioned doses before exposing rats to stress induced highly significant increase in the hypothalamic SP.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631702
03AnimalAnimal study (in vivo)Mechanism
In August rats exposed to stress, single DSIP injections significantly elevated hypothalamic substance P compared with stressed controls.
In plain wordsIn rats exposed to stress, one DSIP injection raised brain substance P more than in stressed rats without DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseHypothalamic substance P after single DSIP injection in stress
Study
ratn: not reported in source
aggressive-conflict stress
Comparator
Stressed rats without DSIP
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Single DSIP injections also significantly elevated SP values, reduced the adrenal hypertrophy and the thymus involution resulting in an increase of the rats' survival as compared to the control animals exposed to stress without DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631703
04AnimalAnimal study (in vivo)Efficacy outcome
In August rats exposed to stress, single DSIP injections reduced adrenal hypertrophy compared with stressed controls.
In plain wordsIn rats exposed to stress, DSIP reduced stress-related adrenal gland enlargement compared with stressed rats without DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseAdrenal hypertrophy in stress
Study
ratn: not reported in source
aggressive-conflict stress
Comparator
Stressed rats without DSIP
Outcome group
Anxiety and mood · Endocrine and hormones
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Single DSIP injections also significantly elevated SP values, reduced the adrenal hypertrophy and the thymus involution resulting in an increase of the rats' survival as compared to the control animals exposed to stress without DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631704
05AnimalAnimal study (in vivo)Efficacy outcome
In August rats exposed to stress, single DSIP injections reduced thymus involution compared with stressed controls.
In plain wordsIn rats exposed to stress, DSIP reduced stress-related thymus shrinkage compared with stressed rats without DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
DecreaseThymus involution in stress
Study
ratn: not reported in source
aggressive-conflict stress
Comparator
Stressed rats without DSIP
Outcome group
Immune response · Immune and inflammation
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Single DSIP injections also significantly elevated SP values, reduced the adrenal hypertrophy and the thymus involution resulting in an increase of the rats' survival as compared to the control animals exposed to stress without DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631705
06AnimalAnimal study (in vivo)Efficacy outcome
In August rats exposed to stress, single DSIP injections increased survival compared with stressed controls.
In plain wordsIn rats exposed to stress, DSIP raised survival compared with stressed rats without DSIP.
Peptide
Delta sleep-inducing peptide (DSIP)
Outcome
IncreaseSurvival in stress
Study
ratn: not reported in source
aggressive-conflict stress
Comparator
Stressed rats without DSIP
Outcome group
Mortality · Whole body
Studied dose
60 and 120 nM/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Single DSIP injections also significantly elevated SP values, reduced the adrenal hypertrophy and the thymus involution resulting in an increase of the rats' survival as compared to the control animals exposed to stress without DSIP.
1 context sentence(design, population, supporting numbers)
Summary · context
In the work was studied the effect of the delta-sleep inducing peptide (DSIP) on the substance P (SP) content in the hypothalamus of August rats genetically predisposed to emotional stress.
Report a problemFND-0768631706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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