Status unknownPhase 2NCT02917928
The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health
Monash Universityn = 40Oct 2016 to est. Jul 2023
Poor Glycemic Control · Cardiovascular Risk Factors · Cognitive Function 1, Social
L-carnosine / Studies
Natural peptide · 2 amino acids · 226.2 Da
L-carnosine studies and research data
PepBank has 202 L-carnosine studies with results. 182 of them gave L-carnosine, with 1,203 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.
Searches 1,203 results and 273 papers. Newer studies from Europe PMC
Results in people
216
18% of 1,203 results
Results in animals
842
70% of 1,203 results
Results in lab cells
145
12% of 1,203 results
From computer models
0
0% of 1,203 results
The molecule
L-carnosine identity
Identifiers, parent molecule, targets and development stage, from curated data.
L-carnosine is beta-alanyl-L-histidine. It occurs naturally and differs from anserine, homocarnosine, N-acetylcarnosine and zinc-carnosine complexes. The literature scope covers administration of L-carnosine to people or animals.
- Kind
- Natural peptide · 2 residues
- Identifiers
- ChEMBLCHEMBL242948 (opens in a new tab)PubChem CID439224 (opens in a new tab)UNII8HO6PVN24W (opens in a new tab)DrugBankDB11695 (opens in a new tab)CAS305-84-0KEGGC00386 (opens in a new tab)IUPHAR4559 (opens in a new tab)
- Development
- Phase 2NCT02917928 registers Phase 2 carnosine supplementation. NCT03314987 registers a completed human intervention with phase not applicable. Neither record establishes medicinal approval. Source (opens in a new tab)
Targets
| Target | Action | Evidence |
|---|---|---|
| Angiotensin-converting enzymeP12821 (opens in a new tab) | Not stated | Not statedSource (opens in a new tab) |
Sequence and structure
Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.
Sequence
2 amino acids · 1 modification
H-
Residues 1 to 2:
H
Properties
From identity sources
- Formula
- C9H14N4O3
- Molecular weight
- 226.23 g/mol
- Monoisotopic mass
- 226.1066 Da
- PubChem CID 439224(opens in a new tab)retrieved 2026-10-27
- GSRS UNII 8HO6PVN24W(opens in a new tab)retrieved 2026-10-27
- iuphar gtopdb 4559(opens in a new tab)retrieved 2026-10-27
Calculated from the sequence
Some values cannot be calculated. The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.
- Average mass
- Not calculated
- Monoisotopic mass
- Not calculated
- Isoelectric point (pI)
- Not calculated
- Net charge at pH 7.4
- Not calculated
- GRAVY (hydropathy)
- Not calculated
- Extinction coefficient, 280 nm (Cys reduced)
- 0 M⁻¹ cm⁻¹
- 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam)
- No Trp or Tyr: absorbance at 280 nm cannot measure this peptide.
- Instability index
- Not calculated
- Aliphatic index
- Not calculated
- Boman index
- Not calculated
- Hydrophobic moment (μH)
- Not calculated
- 1 non-canonical residue (X) is not included in calculated values.
- Defined and validated for proteins; use with care for short peptides.
- Assumes an ideal alpha helix. Many short peptides are not helical.
@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses
Net charge by pH
No charge curve
The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.
Composition
- Positive50% (1)H
- Non-canonical50% (1)X
2 residues. Each residue counts in one class; F and W count as aromatic.
A Ala0 · 0%
I Ile0 · 0%
L Leu0 · 0%
M Met0 · 0%
V Val0 · 0%
F Phe0 · 0%
W Trp0 · 0%
Y Tyr0 · 0%
H His1 · 50%
K Lys0 · 0%
R Arg0 · 0%
D Asp0 · 0%
E Glu0 · 0%
N Asn0 · 0%
Q Gln0 · 0%
S Ser0 · 0%
T Thr0 · 0%
C Cys0 · 0%
G Gly0 · 0%
P Pro0 · 0%
X Xaa1 · 50%
3D structure
No 3D structure
No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.
2D structure
Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).
SMILES fromPubChem CID 439224(opens in a new tab)
C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)CCNResults by area
What the studies measured
People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.
Trials and papers
Newer studies
PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.
Status and safety
Data