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Study · Randomized controlled trial · n = 22 · 2018

3 results

Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial.

Baye E, Ukropec J, de Courten MPJ, Mousa A, Kurdiova T, Johnson J, Wilson K, Plebanski M, Aldini G, Ukropcova B, de Courten B

Nutrients7 Sept 2018Cited by 22 (Europe PMC)

PMID30205427 (opens in a new tab)PMCIDPMC6165206 (opens in a new tab)DOI10.3390/nu10091258 (opens in a new tab)PepBankPUB-30205427
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Summary

Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has not been investigated. Herein we further determined the effect of carnosine supplementation on serum adipsin, resistin and leptin. Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks. Serum adipsin, leptin and resistin were analyzed using a bead-based multiplex assay. Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: -35 ± 83 carnosine vs. 35 ± 55 ng/mL placebo, p = 0.04). There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (-76 ± 165 ng/mL carnosine vs. 20 ± 28 ng/mL placebo, p = 0.06). The changes in leptin and resistin concentrations were inversely related to the change in concentration for urinary carnosine (r = -0.72, p = 0.0002; r = -0.67, p = 0.0009, respectively), carnosine-propanal (r = -0.56, p = 0.005; r = -0.63, p = 0.001, respectively) and carnosine-propanol (r = -0.61, p = 0.002; r = -0.60, p = 0.002, respectively). There were no differences between groups in change in adipsin concentrations. Our findings show carnosine supplementation may normalize some, but not all, of the serum adipokine concentrations involved in glucose metabolism, in overweight and obese individuals. Further clinical trials with larger samples are needed to confirm these results.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In overweight or obese adults, carnosine decreased serum resistin versus placebo.

    In plain wordsIn overweight or obese adults, carnosine decreased serum resistin versus placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseSerum resistin
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Adipokines · Metabolic and weight
    Studied dose
    2 g · 12 weeksAs given in this study (human).

    Measurements

    Resistin change
    −35 ng/mL
    carnosine
    Resistin change
    35 ng/mL
    placebo

    Source sentences

    Summary
    Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: -35 ± 83 carnosine vs. 35 ± 55 ng/mL placebo, p = 0.04).
    1 context sentence
    Summary · context
    Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In overweight or obese adults, carnosine showed a trend toward lower leptin versus placebo, with p = 0.06.

    In plain wordsIn overweight or obese adults, carnosine showed a trend toward lower leptin versus placebo, with p = 0.06.

    Peptide
    L-carnosine
    Outcome
    No significant changeSerum leptin
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Adipokines · Metabolic and weight
    Studied dose
    2 g · 12 weeksAs given in this study (human).

    Measurements

    Leptin change
    −76 ng/mL
    carnosine
    Leptin change
    20 ng/mL
    placebo

    Source sentences

    Summary
    There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (-76 ± 165 ng/mL carnosine vs. 20 ± 28 ng/mL placebo, p = 0.06).
    1 context sentence
    Summary · context
    Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In overweight or obese adults, adipsin changes did not differ between carnosine and placebo groups.

    In plain wordsIn overweight or obese adults, adipsin changes did not differ between carnosine and placebo groups.

    Peptide
    L-carnosine
    Outcome
    No significant changeSerum adipsin
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Adipokines · Metabolic and weight
    Studied dose
    2 g · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    There were no differences between groups in change in adipsin concentrations.
    1 context sentence
    Summary · context
    Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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