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Study · Animal study (in vivo) · mouse · 2024

2 results

Oral Supplementation of L-Carnosine Attenuates Acute-Stress-Induced Corticosterone Release and Mitigates Anxiety in CD157 Knockout Mice.

Tsuji T, Furuhara K, Guo E, Wu Y, Zhong J, Higashida H, Yamamoto Y, Tsuji C

Nutrients23 Aug 2024Cited by 1 (Europe PMC)

PMID39275136 (opens in a new tab)PMCIDPMC11396873 (opens in a new tab)DOI10.3390/nu16172821 (opens in a new tab)PepBankPUB-39275136
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Summary

Corticosterone, an end product of the hypothalamic-pituitary-adrenal (HPA) axis, is a crucial stress hormone. A dysregulated HPA axis and corticosterone release play pivotal roles in the onset and persistence of symptoms of stress-related psychiatric disorders, such as anxiety. The intake of nutrients, probiotics, and prebiotic supplements decreases blood corticosterone levels. The dipeptide L-carnosine is composed of beta-alanine and L-histidine and is commercially available as a nutritional supplement for recovery from fatigue. L-carnosine is involved in stress-induced corticosterone responses and anxiety behaviors in rodents. Here, we assessed the effect of L-carnosine in CD157 knockout (KO) mice, a murine model of autism spectrum disorder (ASD). The uptake of L-carnosine suppressed the increase in plasma corticosterone levels in response to acute stress and attenuated anxiety-like behaviors in CD157 KO mice. These results suggest that L-carnosine supplementation may relieve anxiety by suppressing excessive stress responses in individuals with ASD.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In CD157 knockout mice, L‑carnosine suppressed the plasma corticosterone increase after acute stress.

    In plain wordsIn mice lacking CD157, L‑carnosine reduced the rise in stress hormone after acute stress.

    Peptide
    L-carnosine
    Outcome
    DecreaseAcute-stress plasma corticosterone
    Study

    mousen: not reported in source

    CD157 knockout mice
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    The uptake of L-carnosine suppressed the increase in plasma corticosterone levels in response to acute stress and attenuated anxiety-like behaviors in CD157 KO mice.
    1 context sentence
    Summary · context
    Here, we assessed the effect of L-carnosine in CD157 knockout (KO) mice, a murine model of autism spectrum disorder (ASD).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In CD157 knockout mice, L‑carnosine attenuated anxiety-like behaviors.

    In plain wordsIn mice lacking CD157, L‑carnosine reduced anxiety-like behavior.

    Peptide
    L-carnosine
    Outcome
    DecreaseAnxiety-like behaviors
    Study

    mousen: not reported in source

    CD157 knockout mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    The uptake of L-carnosine suppressed the increase in plasma corticosterone levels in response to acute stress and attenuated anxiety-like behaviors in CD157 KO mice.
    1 context sentence
    Summary · context
    Here, we assessed the effect of L-carnosine in CD157 knockout (KO) mice, a murine model of autism spectrum disorder (ASD).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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