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Study · Animal study (in vivo) · rat · 1982

5 results

Carnosine, histidine, and wound healing.

Fitzpatrick DW, Fisher H

Surgery1 Jan 1982Cited by 22 (Europe PMC)

PMID7054908 (opens in a new tab)PepBankPUB-07054908
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In wounded rats on a low-histidine diet, carnosine treatment increased tissue free-histidine concentrations.

    In plain wordsIn wounded rats with low dietary histidine, carnosine increased tissue free histidine.

    Peptide
    L-carnosine
    Outcome
    IncreaseTissue free-histidine concentration
    Study

    ratn: not reported in source

    skin incision in histidine-deficient or histidine-sufficient rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 mg/100 gm body weight/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Histidine and carnosine treatment (1 mg/100 gm body weight/day intraperitoneally) for 7 days after wounding increased tissue free-histidine concentrations
    2 context sentences
    Summary · context
    Treatment with carnosine was similar, but slightly better than treatment with histidine.
    Summary · context
    The relationships among carnosine, histidine, and wound healing were examined in rats fed either 100% or 50% of the reported histidine required for growth.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wounded rats on a low-histidine diet, carnosine restored skin-breaking strength to normal.

    In plain wordsIn wounded rats with low dietary histidine, carnosine restored skin strength to normal.

    Peptide
    L-carnosine
    Outcome
    IncreaseSkin-breaking strength
    Study

    ratn: not reported in source

    skin incision in histidine-deficient or histidine-sufficient rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 mg/100 gm body weight/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Histidine and carnosine treatment (1 mg/100 gm body weight/day intraperitoneally) for 7 days after wounding increased tissue free-histidine concentrations and brought skin-breaking strength and collagen deposition up to "normal" in the animals on the low-histidine diet
    2 context sentences
    Summary · context
    Treatment with carnosine was similar, but slightly better than treatment with histidine.
    Summary · context
    The relationships among carnosine, histidine, and wound healing were examined in rats fed either 100% or 50% of the reported histidine required for growth.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In wounded rats on a low-histidine diet, carnosine restored collagen deposition to normal.

    In plain wordsIn wounded rats with low dietary histidine, carnosine restored collagen deposition to normal.

    Peptide
    L-carnosine
    Outcome
    IncreaseCollagen deposition
    Study

    ratn: not reported in source

    skin incision in histidine-deficient or histidine-sufficient rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 mg/100 gm body weight/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Histidine and carnosine treatment (1 mg/100 gm body weight/day intraperitoneally) for 7 days after wounding increased tissue free-histidine concentrations and brought skin-breaking strength and collagen deposition up to "normal" in the animals on the low-histidine diet
    2 context sentences
    Summary · context
    Treatment with carnosine was similar, but slightly better than treatment with histidine.
    Summary · context
    The relationships among carnosine, histidine, and wound healing were examined in rats fed either 100% or 50% of the reported histidine required for growth.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In histidine-sufficient wounded rats, carnosine treatment did not further improve healing.

    In plain wordsIn wounded rats with sufficient dietary histidine, carnosine did not further improve healing.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedHealing in histidine-sufficient animals
    Study

    ratn: not reported in source

    skin incision in histidine-deficient or histidine-sufficient rats
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 mg/100 gm body weight/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    but did not further improve healing in the histidine-sufficient animals.
    2 context sentences
    Summary · context
    Treatment with carnosine was similar, but slightly better than treatment with histidine.
    Summary · context
    The relationships among carnosine, histidine, and wound healing were examined in rats fed either 100% or 50% of the reported histidine required for growth.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In wounded rats, carnosine treatment was similar to, but slightly better than, histidine treatment.

    In plain wordsIn wounded rats, carnosine treatment was similar to, but slightly better than, histidine treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseWound healing versus histidine
    Study

    ratn: not reported in source

    skin incision in histidine-deficient or histidine-sufficient rats
    Comparator
    histidine treatment
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1 mg/100 gm body weight/day · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Treatment with carnosine was similar, but slightly better than treatment with histidine.
    1 context sentence
    Summary · context
    The relationships among carnosine, histidine, and wound healing were examined in rats fed either 100% or 50% of the reported histidine required for growth.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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