In rats, carnosine ameliorated CHOP-induced reproductive alterations compared with CHOP alone.
In plain wordsIn rats, carnosine reduced reproductive changes caused by CHOP compared with CHOP alone.
- Peptide
- L-carnosine
- Outcome
- DecreaseCHOP-induced reproductive alterations
- Study
ratn: not reported in source
CHOP-induced reproductive disorders- Comparator
- CHOP alone
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 250 mg/kg/day · intraperitoneal · 4 cycles each of 3 weeksAs given in this study (rat).
Source sentences
Importantly, administration of carnosine ameliorated CHOP-induced alterations without diminishing CHOP's antineoplastic action.
5 context sentences(design, population, supporting numbers)
CHOP lowered genitals weight, sperm count and motility, testicular function marker enzymes, serum testosterone level and gene expression of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and steroidogenic acute regulatory protein.
Furthermore, CHOP elevated testicular oxidative stress, serum follicle-stimulating hormone, luteinising hormone and triggered DNA damage.
Group II received carnosine (250mg kg day-1 , i.p.); Group III received CHOP: cyclophosphamide (27 mg/kg/cycle), doxorubicin (1.8 mg/kg/cycle) and vincristine (0.05 mg/kg /cycle) by i.p. plus oral prednisone (1.47 mg kg-1 day-1 /cycle) for five days.
Group IV received carnosine plus CHOP.
The study involved 4 cycles each of 3 weeks.