Effect of carnosine on rats under experimental brain ischemia.

Gallant S, Kukley M, Stvolinsky S, Bulygina E, Boldyrev A

The Tohoku journal of experimental medicine1 Jun 2000Cited by 30 (Europe PMC)

PMID10946918DOI10.1620/tjem.191.85PepBankPUB-10946918

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, dietary carnosine improved orientation in behavioral tests.
In plain wordsIn rats, dietary carnosine improved orientation in behavioral tests.
Peptide
L-carnosine
Outcome
IncreaseOrientation
Study
ratn: not reported in source
experimental brain ischemia
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
Carnosine was shown to improve the animals orientation and learning in "Open Field" and "T-Maze" tests, and this effect was accompanied with an increase in glutamate binding to N-methyl-D-aspartate (NMDA) receptors in brain synaptosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, dietary carnosine improved learning in behavioral tests.
In plain wordsIn rats, dietary carnosine improved learning in behavioral tests.
Peptide
L-carnosine
Outcome
IncreaseLearning
Study
ratn: not reported in source
experimental brain ischemia
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
Carnosine was shown to improve the animals orientation and learning in "Open Field" and "T-Maze" tests, and this effect was accompanied with an increase in glutamate binding to N-methyl-D-aspartate (NMDA) receptors in brain synaptosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691802
03AnimalAnimal study (in vivo)Mechanism
In rats, carnosine treatment accompanied increased glutamate binding to brain synaptosomal NMDA receptors.
In plain wordsIn rats, carnosine treatment accompanied increased glutamate binding to brain receptors.
Peptide
L-carnosine
Outcome
IncreaseGlutamate binding to NMDA receptors
Study
ratn: not reported in source
experimental brain ischemia
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
Carnosine was shown to improve the animals orientation and learning in "Open Field" and "T-Maze" tests, and this effect was accompanied with an increase in glutamate binding to N-methyl-D-aspartate (NMDA) receptors in brain synaptosomes.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691803
04AnimalAnimal study (in vivo)Safety outcome
In rats, carnosine reduced mortality after ischemia from 55% to 17%.
In plain wordsIn rats, carnosine reduced deaths after ischemia compared with untreated rats.
Peptide
L-carnosine
Outcome
DecreaseMortality after ischemia
Study
ratn: not reported in source
experimental brain ischemia
Comparator
ischemic untreated rats
Outcome group
Mortality · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
In the group of rats treated with carnosine, mortality after ischemic attack was decreased (from 55% to 17%) and most of the learning parameters were kept at the pre-ischemic level.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691804
05AnimalAnimal study (in vivo)Efficacy outcome
In carnosine-treated rats, most learning parameters remained at their pre-ischemic levels.
In plain wordsIn rats given carnosine, most learning measures stayed at their levels before ischemia.
Peptide
L-carnosine
Outcome
No significant changeLearning after ischemia
Study
ratn: not reported in source
experimental brain ischemia
Comparator
pre-ischemic level
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
In the group of rats treated with carnosine, mortality after ischemic attack was decreased (from 55% to 17%) and most of the learning parameters were kept at the pre-ischemic level.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691805
06AnimalAnimal study (in vivo)Mechanism
In rats, brain MAO B activity did not change significantly with ischemia during carnosine treatment, compared with ischemic untreated rats.
In plain wordsIn rats, brain MAO B activity showed no significant change with ischemia during carnosine treatment, compared with untreated ischemic rats.
Peptide
L-carnosine
Outcome
No significant changeBrain MAO B activity
Study
ratn: not reported in source
experimental brain ischemia
Comparator
ischemic untreated rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
Monoamine oxidase B (MAO B) activity in brain of the carnosine treated rats was not changed by ischemia significantly (compared to that of ischemic untreated rats)
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691806
07AnimalAnimal study (in vivo)Mechanism
In rats, carnosine suppressed ischemia-elevated NMDA binding to brain membranes to the normal brain level.
In plain wordsIn rats, carnosine reduced elevated NMDA binding after ischemia to the normal level, compared with untreated ischemic rats.
Peptide
L-carnosine
Outcome
DecreaseNMDA binding after ischemia
Study
ratn: not reported in source
experimental brain ischemia
Comparator
ischemic untreated rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · dietaryAs given in this study (rat).
Source sentences
Summary
but NMDA binding to brain synaptosomal membranes being increased by ischemic attack was significantly suppressed and reached the level characteristic of normal brain.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of dietary carnosine on the behavioral and biochemical characteristics of rats under experimental ischemia was studied.
Report a problemFND-1094691807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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