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Study · Animal study (in vivo) · dog · 1985

4 results

Net release or uptake of histidine and carnosine in kidney of dogs.

Cianciaruso B, Fukuda S, Jones MR, Kopple JD

The American journal of physiology1 Jan 1985Cited by 1 (Europe PMC)

PMID3966550 (opens in a new tab)DOI10.1152/ajpendo.1985.248.1.e51 (opens in a new tab)PepBankPUB-03966550
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In female dogs, carnosine infusion markedly increased renal histidine release compared with saline infusion.

    In plain wordsIn dogs, carnosine infusion increased kidney histidine release compared with saline infusion.

    Peptide
    L-carnosine
    Outcome
    IncreaseRenal histidine release
    Study

    dogn = 19

    female dogs fed histidine-free or histidine-containing diets
    Comparator
    half-normal saline infusion
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50 mumol/min · infusionAs given in this study (dog).

    Source sentences

    Summary
    During carnosine infusion, Qmet histidine increased markedly, and there was net renal uptake of carnosine.
    3 context sentences
    Summary · context
    Renal Qmet histidine, calculated from either plasma or whole blood values, was positive during infusion of half-normal saline.
    Summary · context
    Because one possible source of renal histidine is carnosine (beta-alanyl-L-histidine), we investigated net renal production (release) or utilization (uptake) (Qmet) of histidine and carnosine in 19 female dogs after they were fed histidine-free (9 dogs) or histidine-containing diets (10 dogs).
    Summary · context
    Dogs were infused with half-normal saline for 120 min followed by an infusion of half-normal saline containing carnosine, 50 mumol/min.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In female dogs, carnosine infusion produced net renal carnosine uptake.

    In plain wordsIn dogs, kidneys took up carnosine during its infusion.

    Peptide
    L-carnosine
    Outcome
    Not applicableRenal carnosine uptake
    Study

    dogn = 19

    female dogs fed histidine-free or histidine-containing diets
    Outcome group
    Pharmacokinetics · Kidney and urinary
    Studied dose
    50 mumol/min · infusionAs given in this study (dog).

    Source sentences

    Summary
    During carnosine infusion, Qmet histidine increased markedly, and there was net renal uptake of carnosine.
    2 context sentences
    Summary · context
    Because one possible source of renal histidine is carnosine (beta-alanyl-L-histidine), we investigated net renal production (release) or utilization (uptake) (Qmet) of histidine and carnosine in 19 female dogs after they were fed histidine-free (9 dogs) or histidine-containing diets (10 dogs).
    Summary · context
    Dogs were infused with half-normal saline for 120 min followed by an infusion of half-normal saline containing carnosine, 50 mumol/min.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In dogs studied with carnosine infusion, renal histidine balance did not differ between histidine-free and histidine-containing diets.

    In plain wordsIn dogs studied with carnosine infusion, kidney histidine balance did not differ between diets with and without histidine.

    Peptide
    L-carnosine
    Outcome
    No significant changeRenal histidine balance by diet
    Study

    dogn = 19

    female dogs fed histidine-free or histidine-containing diets
    Comparator
    histidine-containing diet
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50 mumol/min · infusionAs given in this study (dog).

    Source sentences

    Summary
    The Qmet histidine and carnosine were not different in the dogs fed histidine-free vs. histidine-containing diets.
    2 context sentences
    Summary · context
    Because one possible source of renal histidine is carnosine (beta-alanyl-L-histidine), we investigated net renal production (release) or utilization (uptake) (Qmet) of histidine and carnosine in 19 female dogs after they were fed histidine-free (9 dogs) or histidine-containing diets (10 dogs).
    Summary · context
    Dogs were infused with half-normal saline for 120 min followed by an infusion of half-normal saline containing carnosine, 50 mumol/min.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In dogs studied with carnosine infusion, renal carnosine balance did not differ between histidine-free and histidine-containing diets.

    In plain wordsIn dogs studied with carnosine infusion, kidney carnosine balance did not differ between diets with and without histidine.

    Peptide
    L-carnosine
    Outcome
    No significant changeRenal carnosine balance by diet
    Study

    dogn = 19

    female dogs fed histidine-free or histidine-containing diets
    Comparator
    histidine-containing diet
    Outcome group
    Pharmacokinetics · Kidney and urinary
    Studied dose
    50 mumol/min · infusionAs given in this study (dog).

    Source sentences

    Summary
    The Qmet histidine and carnosine were not different in the dogs fed histidine-free vs. histidine-containing diets.
    2 context sentences
    Summary · context
    Because one possible source of renal histidine is carnosine (beta-alanyl-L-histidine), we investigated net renal production (release) or utilization (uptake) (Qmet) of histidine and carnosine in 19 female dogs after they were fed histidine-free (9 dogs) or histidine-containing diets (10 dogs).
    Summary · context
    Dogs were infused with half-normal saline for 120 min followed by an infusion of half-normal saline containing carnosine, 50 mumol/min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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