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Study · Animal study (in vivo) · mouse and rat · 2012

2 results

Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation.

Horii Y, Shen J, Fujisaki Y, Yoshida K, Nagai K

Neuroscience letters5 Jan 2012Cited by 36 (Europe PMC)

PMID22240100 (opens in a new tab)DOI10.1016/j.neulet.2011.12.058 (opens in a new tab)PepBankPUB-22240100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, intraduodenal L‑carnosine significantly suppressed splenic sympathetic nerve activity.

    In plain wordsIn rats under anesthesia, L‑carnosine reduced splenic sympathetic nerve activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseSplenic sympathetic nerve activity
    Study

    ratn: not reported in source

    Urethane-anesthetized rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    3.3 mg/kg · intraduodenalAs given in this study (rat).

    Source sentences

    Summary
    In the present study, we examined the effects of intraduodenal (ID) injection of l-carnosine on splenic sympathetic nerve activity (splenic-SNA) in urethane-anesthetized rats and found that ID injection of 3.3mg/kg of body weight of l-carnosine significantly suppressed splenic-SNA.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with transplanted human colon cancer cells, L‑carnosine drinking water inhibited tumor proliferation.

    In plain wordsIn mice with transplanted human colon cancer cells, L‑carnosine drinking water inhibited tumor growth.

    Peptide
    L-carnosine
    Outcome
    DecreaseTumor proliferation
    Study

    mousen: not reported in source

    Human colon cancer cells transplanted into athymic nude mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 mg/mL · oral drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    The findings of this study revealed that 1mg/mL of l-carnosine solution given as the only drinking water inhibited tumor proliferation.
    1 context sentence
    Summary · context
    Since it has been suggested that splenic-SNA reduction increases natural killer (NK) activity of splenic cells, which in turn elevates tumor immunity, we then investigated the effect of l-carnosine on the proliferation of human colon cancer cells transplanted into athymic nude mice.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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