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Study · Animal study (in vivo) · mouse · 2019

10 results

Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine.

Cheng JY, Yang JB, Liu Y, Xu M, Huang YY, Zhang JJ, Cao P, Lyu JX, Shen Y

Acta pharmacologica Sinica18 Dec 2018Cited by 22 (Europe PMC)

PMID30560903 (opens in a new tab)PMCIDPMC6786397 (opens in a new tab)DOI10.1038/s41401-018-0182-8 (opens in a new tab)PepBankPUB-30560903
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In xenograft nude mice, carnosine significantly inhibited tumor growth.

    In plain wordsIn mice, carnosine significantly inhibited tumor growth.

    Peptide
    L-carnosine
    Outcome
    DecreaseTumor growth
    Study

    mousen: not reported in source

    SGC-7901 xenograft nude mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    250 mg kg/d · ip · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In SGC-7901 cell xenograft nude mice, administration of carnosine (250 mg kg/d, ip, for 3 weeks) significantly inhibited the tumor growth and decreased the expression of mitochondrial PHB-1 in tumor tissue.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In xenograft nude mice, carnosine decreased mitochondrial PHB-1 expression in tumor tissue.

    In plain wordsIn mice, carnosine decreased mitochondrial PHB-1 expression in tumor tissue.

    Peptide
    L-carnosine
    Outcome
    DecreaseMitochondrial PHB-1 expression
    Study

    mousen: not reported in source

    SGC-7901 xenograft nude mice
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    250 mg kg/d · ip · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In SGC-7901 cell xenograft nude mice, administration of carnosine (250 mg kg/d, ip, for 3 weeks) significantly inhibited the tumor growth and decreased the expression of mitochondrial PHB-1 in tumor tissue.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  3. 03LabIn vitro (cells)Mechanism

    In gastric cancer experiments, carnosine hydrolysis was not required for its anti-cancer effect.

    In plain wordsIn lab tests, carnosine hydrolysis was not required for its anti-cancer effect.

    Peptide
    L-carnosine
    Outcome
    Not applicableHydrolysis requirement
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We firstly showed that hydrolysis of carnosine was not a prerequisite for its anti-gastric cancer effect.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  4. 04LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine significantly decreased mitochondrial respiratory chain complex I activity.

    In plain wordsIn cells, carnosine significantly decreased mitochondrial respiratory chain complex I activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseRespiratory chain complex I activity
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  5. 05LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine significantly decreased mitochondrial respiratory chain complex II activity.

    In plain wordsIn cells, carnosine significantly decreased mitochondrial respiratory chain complex II activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseRespiratory chain complex II activity
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  6. 06LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine significantly decreased mitochondrial respiratory chain complex III activity.

    In plain wordsIn cells, carnosine significantly decreased mitochondrial respiratory chain complex III activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseRespiratory chain complex III activity
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  7. 07LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine significantly decreased mitochondrial respiratory chain complex IV activity.

    In plain wordsIn cells, carnosine significantly decreased mitochondrial respiratory chain complex IV activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseRespiratory chain complex IV activity
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  8. 08LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine significantly decreased mitochondrial ATP production.

    In plain wordsIn cells, carnosine significantly decreased mitochondrial ATP production.

    Peptide
    L-carnosine
    Outcome
    DecreaseMitochondrial ATP production
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  9. 09LabIn vitro (cells)Mechanism

    In SGC-7901 cells, carnosine downregulated 13 proteins involved in mitochondrial bioenergetics.

    In plain wordsIn cells, carnosine reduced 13 proteins involved in mitochondrial energy production.

    Peptide
    L-carnosine
    Outcome
    DecreaseMitochondrial bioenergetics proteins
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Mitochondrial function · Cancer
    Studied dose
    20 mmol/LAs given in this study (human).

    Source sentences

    Summary
    Treatment of SGC-7901 cells with carnosine (20 mmol/L) significantly decreased the activities of mitochondrial respiratory chain complexes I-IV and mitochondrial ATP production, and downregulated 13 proteins involved in mitochondrial bioenergetics.
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.
  10. 10LabIn vitro (cells)Mechanism

    In gastric cancer cells, carnosine significantly suppressed Akt phosphorylation.

    In plain wordsIn cells, carnosine significantly suppressed Akt phosphorylation.

    Peptide
    L-carnosine
    Outcome
    DecreaseAkt phosphorylation
    Study

    humann: not reported in source

    SGC-7901 gastric cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, carnosine treatment significantly suppressed the phosphorylation of Akt,
    1 context sentence
    Summary · context
    In the current study we investigated the effect of carnosine on the growth of human gastric cancer SGC-7901 cells in vitro and in vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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