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Study · In vitro (cells) · rat · 2020

5 results

Carnosine attenuates vascular smooth muscle cells calcification through mTOR signaling pathway.

Huang Y, Wang J, Luo M, Yan D, Zhang C

Aging medicine (Milton (N.S.W))1 Sept 2020Cited by 14 (Europe PMC)

PMID33103035 (opens in a new tab)PMCIDPMC7574631 (opens in a new tab)DOI10.1002/agm2.12125 (opens in a new tab)PepBankPUB-33103035
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat vascular smooth muscle cells, carnosine reduced calcium deposition in a dose-dependent manner.

    In plain wordsIn cells from rats, carnosine reduced calcium deposits in a dose-dependent manner.

    Peptide
    L-carnosine
    Outcome
    DecreaseCalcium deposition
    Study

    ratn: not reported in source

    Calcification model of vascular smooth muscle cells
    Outcome group
    Tissue calcification · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine treatment attenuated calcium deposition in a dose-dependent manner, detected by Alizarin Red S staining and calcium content assay.
    1 context sentence
    Summary · context
    In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification.
  2. 02LabIn vitro (cells)Mechanism

    In rat vascular smooth muscle cells, carnosine reduced Runx2 protein levels.

    In plain wordsIn cells from rats, carnosine reduced Runx2 protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseRunx2 protein
    Study

    ratn: not reported in source

    Calcification model of vascular smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine also reduced the protein level of Runx2, bone morphogenetic protein 2 (BMP-2), and cellular reactive oxygen species (ROS) production.
    1 context sentence
    Summary · context
    In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification.
  3. 03LabIn vitro (cells)Mechanism

    In rat vascular smooth muscle cells, carnosine reduced BMP-2 protein levels.

    In plain wordsIn cells from rats, carnosine reduced BMP-2 protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseBMP-2 protein
    Study

    ratn: not reported in source

    Calcification model of vascular smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine also reduced the protein level of Runx2, bone morphogenetic protein 2 (BMP-2), and cellular reactive oxygen species (ROS) production.
    1 context sentence
    Summary · context
    In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification.
  4. 04LabIn vitro (cells)Mechanism

    In rat vascular smooth muscle cells, carnosine reduced cellular reactive oxygen species production.

    In plain wordsIn cells from rats, carnosine reduced reactive oxygen species production.

    Peptide
    L-carnosine
    Outcome
    DecreaseReactive oxygen species
    Study

    ratn: not reported in source

    Calcification model of vascular smooth muscle cells
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Carnosine also reduced the protein level of Runx2, bone morphogenetic protein 2 (BMP-2), and cellular reactive oxygen species (ROS) production.
    1 context sentence
    Summary · context
    In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification.
  5. 05LabIn vitro (cells)Mechanism

    In rat vascular smooth muscle cells, carnosine inhibited mTOR pathway activation.

    In plain wordsIn cells from rats, carnosine reduced mTOR pathway activation.

    Peptide
    L-carnosine
    Outcome
    DecreasemTOR pathway activation
    Study

    ratn: not reported in source

    Calcification model of vascular smooth muscle cells
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Further, carnosine inhibited the activation of the mammalian target of rapamycin (mTOR) pathway.
    1 context sentence
    Summary · context
    In this research, we used an in vitro model of VSMC calcification to investigate the role of carnosine in the progression of rat VSMC calcification.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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