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Study · Animal study (in vivo) · chicken · 2020

5 results

Antioxidative Characteristics of Chicken Breast Meat and Blood after Diet Supplementation with Carnosine, L-histidine, and β-alanine.

Kopec W, Jamroz D, Wiliczkiewicz A, Biazik E, Pudlo A, Korzeniowska M, Hikawczuk T, Skiba T

Antioxidants (Basel, Switzerland)7 Nov 2020Cited by 31 (Europe PMC)

PMID33171823 (opens in a new tab)PMCIDPMC7695160 (opens in a new tab)DOI10.3390/antiox9111093 (opens in a new tab)PepBankPUB-33171823
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Summary

The objective of the study was to test the effect of diets supplemented with β-alanine, L-histidine, and carnosine on the histidine dipeptide content and the antioxidative status of chicken breast muscles and blood. One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar). After 28 days, chicken breast muscles and blood samples were analyzed for the antioxidant enzyme activity (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)), carnosine and anserine content, amino acid profile, and anti-radical activity (ABTS, DPPH, ferric reducing antioxidant power (FRAP)). The results of the study showed that carnosine supplementation effectively increased body weight and breast muscle share in chicken carcasses. Carnosine and L-histidine supplementation with or without β-alanine increased carnosine content in chicken breast muscles up to 20% (p = 0.003), but the boost seems to be too low to affect the potential antioxidant capacity and amino acid content. The β-alanine-enriched diet lowered dipeptide concentration in chicken blood serum (p = 0.002) and activated catalase in chicken breast muscles in relation to the control group (p = 0.003). It can be concluded that histidine or dipeptide supplementation of chicken diets differently affected the total antioxidant potential: in breast muscles, it increased dipeptide content, while in blood cell sediment (rich in erythrocytes), increased SOD and GPx activities were observed.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In chickens, carnosine supplementation increased body weight.

    In plain wordsIn chickens, carnosine supplementation increased body weight.

    Peptide
    L-carnosine
    Outcome
    IncreaseBody weight
    Study

    chickenn: not reported in source

    Hubbard Flex male chickens
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.27% carnosine in diet · oral · 28 daysAs given in this study (chicken).

    Source sentences

    Summary
    The results of the study showed that carnosine supplementation effectively increased body weight and breast muscle share in chicken carcasses.
    1 context sentence
    Summary · context
    One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In chickens, carnosine supplementation increased breast muscle share in carcasses.

    In plain wordsIn chickens, carnosine supplementation increased the breast muscle share of carcasses.

    Peptide
    L-carnosine
    Outcome
    IncreaseBreast muscle share
    Study

    chickenn: not reported in source

    Hubbard Flex male chickens
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    0.27% carnosine in diet · oral · 28 daysAs given in this study (chicken).

    Source sentences

    Summary
    The results of the study showed that carnosine supplementation effectively increased body weight and breast muscle share in chicken carcasses.
    1 context sentence
    Summary · context
    One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar).
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In chickens, carnosine supplementation increased breast muscle carnosine content; the reported increase also covers histidine regimens.

    In plain wordsIn chickens, carnosine increased breast muscle carnosine content, but the reported increase also covers other regimens.

    Peptide
    L-carnosine
    Outcome
    IncreaseBreast muscle carnosine content
    Study

    chickenn: not reported in source

    Hubbard Flex male chickens
    Outcome group
    Endogenous peptide levels · Musculoskeletal
    Studied dose
    0.27% carnosine in diet · oral · 28 daysAs given in this study (chicken).

    Source sentences

    Summary
    Carnosine and L-histidine supplementation with or without β-alanine increased carnosine content in chicken breast muscles up to 20% (p = 0.003), but the boost seems to be too low to affect the potential antioxidant capacity and amino acid content.
    1 context sentence
    Summary · context
    One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar).
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In chickens, carnosine supplementation did not affect potential antioxidant capacity.

    In plain wordsIn chickens, carnosine supplementation did not affect potential antioxidant capacity.

    Peptide
    L-carnosine
    Outcome
    No significant changePotential antioxidant capacity
    Study

    chickenn: not reported in source

    Hubbard Flex male chickens
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    0.27% carnosine in diet · oral · 28 daysAs given in this study (chicken).

    Source sentences

    Summary
    Carnosine and L-histidine supplementation with or without β-alanine increased carnosine content in chicken breast muscles up to 20% (p = 0.003), but the boost seems to be too low to affect the potential antioxidant capacity and amino acid content.
    1 context sentence
    Summary · context
    One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar).
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In chickens, carnosine supplementation did not affect amino acid content.

    In plain wordsIn chickens, carnosine supplementation did not affect amino acid content.

    Peptide
    L-carnosine
    Outcome
    No significant changeAmino acid content
    Study

    chickenn: not reported in source

    Hubbard Flex male chickens
    Outcome group
    Protein and amino acid metabolism · Musculoskeletal
    Studied dose
    0.27% carnosine in diet · oral · 28 daysAs given in this study (chicken).

    Source sentences

    Summary
    Carnosine and L-histidine supplementation with or without β-alanine increased carnosine content in chicken breast muscles up to 20% (p = 0.003), but the boost seems to be too low to affect the potential antioxidant capacity and amino acid content.
    1 context sentence
    Summary · context
    One-day-old Hubbard Flex male chickens were assigned to five treatments: control diet (C) and control diet supplemented with 0.18% L-histidine (ExpH), 0.3% β-alanine (ExpA), a mix of L-histidine\β-alanine (ExpH+A), and 0.27% carnosine (ExpCar).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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