Antihyperlipidemic potential of dietary supplementation with carnosine in high-fat diet-fed rats.

Rašković A, Martić N, Zaklan D, Duborija-Kovačević N, Vujčić M, Andrejić-Višnjić B, Čapo I, Mijović R, Krga M, Pavlović N, Prodanović D, Arsenović P, Horvat O

European review for medical and pharmacological sciences1 Feb 2023Cited by 7 (Europe PMC)

PMID36808356DOI10.26355/eurrev_202302_31211PepBankPUB-36808356

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, carnosine effects on triglyceride metabolism were less evident than effects on cholesterol.
In plain wordsIn rats with high blood lipids, carnosine effects on triglycerides were less evident than effects on cholesterol.
Peptide
L-carnosine
Outcome
Direction not reportedTriglyceride metabolism
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · oral gavageAs given in this study (rat).
Source sentences
Summary
The effect of carnosine on the metabolism of triglycerides was not as evident as in the case of cholesterol.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
Report a problemFND-3680835603
02AnimalAnimal study (in vivo)Safety outcome
In hyperlipidemic rats, the abstract reports a good carnosine safety profile for liver function without numerical results.
In plain wordsIn rats with high blood lipids, the abstract reports a good carnosine safety profile for liver function.
Peptide
L-carnosine
Outcome
Direction not reportedLiver function safety
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Adverse events · Liver
Studied dose
Dose not stated · oral gavageAs given in this study (rat).
Source sentences
Summary
Besides, the good safety profile of carnosine in terms of its effect on liver and kidney functions was also confirmed.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
Report a problemFND-3680835607
03AnimalAnimal study (in vivo)Safety outcome
In hyperlipidemic rats, the abstract reports a good carnosine safety profile for kidney function without numerical results.
In plain wordsIn rats with high blood lipids, the abstract reports a good carnosine safety profile for kidney function.
Peptide
L-carnosine
Outcome
Direction not reportedKidney function safety
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Adverse events · Kidney and urinary
Studied dose
Dose not stated · oral gavageAs given in this study (rat).
Source sentences
Summary
Besides, the good safety profile of carnosine in terms of its effect on liver and kidney functions was also confirmed.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
Report a problemFND-3680835608

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

04AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, a carnosine-based supplement improved serum total cholesterol, especially with simvastatin.
In plain wordsIn rats with high blood lipids, a carnosine-based supplement improved total cholesterol, especially with simvastatin.
Peptide
L-carnosine
Outcome
DecreaseTotal cholesterol
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Treatment with a carnosine-based supplement significantly improved total and LDL cholesterol levels in serum, especially in the combination with simvastatin as a conventional drug in dyslipidemia treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3680835601
05AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, a carnosine-based supplement improved serum LDL cholesterol, especially with simvastatin.
In plain wordsIn rats with high blood lipids, a carnosine-based supplement improved LDL cholesterol, especially with simvastatin.
Peptide
L-carnosine
Outcome
DecreaseLDL cholesterol
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Treatment with a carnosine-based supplement significantly improved total and LDL cholesterol levels in serum, especially in the combination with simvastatin as a conventional drug in dyslipidemia treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3680835602
06AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, carnosine with simvastatin was among the most effective regimens for lowering the atherogenic index.
In plain wordsIn rats with high blood lipids, carnosine with simvastatin was among the most effective regimens for lowering the atherogenic index.
Peptide
L-carnosine
Outcome
DecreaseAtherogenic index with carnosine and simvastatin
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Nevertheless, the values of the atherogenic index showed that the combinations of carnosine and carnosine supplement with simvastatin were the most effective in lowering this comprehensive lipid index.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3680835604
07AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, carnosine supplement with simvastatin was among the most effective regimens for lowering the atherogenic index.
In plain wordsIn rats with high blood lipids, carnosine supplement with simvastatin was among the most effective regimens for lowering the atherogenic index.
Peptide
L-carnosine
Outcome
DecreaseAtherogenic index with supplement and simvastatin
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Lipids · Metabolic and weight
Source sentences
Summary
Nevertheless, the values of the atherogenic index showed that the combinations of carnosine and carnosine supplement with simvastatin were the most effective in lowering this comprehensive lipid index.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3680835605
08AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In hyperlipidemic rats, dietary carnosine supplementation showed anti-inflammatory effects on immunohistochemical analysis.
In plain wordsIn rats with high blood lipids, dietary carnosine supplementation showed anti-inflammatory effects.
Peptide
L-carnosine
Outcome
DecreaseInflammation
Study
ratn: not reported in source
High-fat diet-induced hyperlipidemia in adult male Wistar rats
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Dietary carnosine supplementation resulted also in anti-inflammatory effects, as demonstrated by immunohistochemical analyses.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted on adult male Wistar rats, divided into control and experimental groups.
Summary · context
Animals were kept in standard laboratory conditions and according to groups were treated with saline, carnosine, carnosine dietary supplement, simvastatin, and their combinations.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3680835606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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