Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats.

Kozan R, Sefil F, Bağirici F

Brain research16 Aug 2008Cited by 17 (Europe PMC)

PMID18773880DOI10.1016/j.brainres.2008.08.019PepBankPUB-18773880

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, mean spike frequency was significantly lower in all carnosine-treated groups than in penicillin-injected rats.
In plain wordsIn rats, carnosine reduced mean spike frequency compared with penicillin-injected rats.
Peptide
L-carnosine
Outcome
DecreaseMean spike frequency after treatment
Study
ratn: not reported in source
intracortical penicillin-induced epileptiform activity
Comparator
penicillin-injected rats
Outcome group
Seizures · Nervous system and cognition
Studied dose
125, 250, 500, 1000 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The mean spike frequency of penicillin-induced epileptiform activity was significantly decreased in all carnosine-treated rats when compared with those of penicillin-injected.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of carnosine in a rat model of epilepsy using the intracortical penicillin injection method. Thirty minutes after penicillin injection, the doses of 125, 250, 500, 1000 mg/kg carnosine and 90 min before penicillin injection the dose of 500 mg/kg carnosine w…
Report a problemFND-1877388001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine at 500 mg/kg was the most effective tested treatment dose for reducing epileptiform spike frequency.
In plain wordsIn rats, carnosine at 500 mg/kg reduced spike frequency most effectively among the tested treatment doses.
Peptide
L-carnosine
Outcome
DecreaseMost effective treatment dose for spike frequency
Study
ratn: not reported in source
intracortical penicillin-induced epileptiform activity
Comparator
other tested carnosine doses
Outcome group
Seizures · Nervous system and cognition
Studied dose
500 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The dose of 500 mg/kg for carnosine treated and pretreated rats was found to be the most effective dose in reducing the frequency of penicillin-induced epileptiform activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of carnosine in a rat model of epilepsy using the intracortical penicillin injection method. Thirty minutes after penicillin injection, the doses of 125, 250, 500, 1000 mg/kg carnosine and 90 min before penicillin injection the dose of 500 mg/kg carnosine w…
Report a problemFND-1877388002
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine pretreatment at 500 mg/kg was reported as most effective in reducing epileptiform spike frequency.
In plain wordsIn rats, carnosine pretreatment at 500 mg/kg was reported as most effective in reducing epileptiform spike frequency.
Peptide
L-carnosine
Outcome
DecreaseSpike frequency with pretreatment
Study
ratn: not reported in source
intracortical penicillin-induced epileptiform activity
Outcome group
Seizures · Nervous system and cognition
Studied dose
500 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The dose of 500 mg/kg for carnosine treated and pretreated rats was found to be the most effective dose in reducing the frequency of penicillin-induced epileptiform activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of carnosine in a rat model of epilepsy using the intracortical penicillin injection method. Thirty minutes after penicillin injection, the doses of 125, 250, 500, 1000 mg/kg carnosine and 90 min before penicillin injection the dose of 500 mg/kg carnosine w…
Report a problemFND-1877388003
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, carnosine pretreatment did not significantly change the mean onset of epileptiform activity versus the penicillin group.
In plain wordsIn rats, carnosine pretreatment did not significantly change epileptiform activity onset compared with penicillin alone.
Peptide
L-carnosine
Outcome
No significant changeEpileptiform activity onset
Study
ratn: not reported in source
intracortical penicillin-induced epileptiform activity
Comparator
penicillin group
Outcome group
Seizures · Nervous system and cognition
Studied dose
500 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
There was no significant difference in the mean onset of epileptiform activity between penicillin and 500 mg/kg carnosine pretreated groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the effects of carnosine in a rat model of epilepsy using the intracortical penicillin injection method. Thirty minutes after penicillin injection, the doses of 125, 250, 500, 1000 mg/kg carnosine and 90 min before penicillin injection the dose of 500 mg/kg carnosine w…
Report a problemFND-1877388004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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