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Study · Animal study (in vivo) · mouse · 2026

7 results

Carnosine augments the efficacy of pulmonary rehabilitation in COPD: insights from a preclinical model.

Almerdasi SA, Chan SMH, Alateeq RA, Wang W, De Luca S, Akhtar A, Mou K, Seow HJ, Bozinovski S, Selemidis S, Selemidis S, Vlahos R

Clinical science (London, England : 1979)1 Jun 2026

PMID42024405 (opens in a new tab)DOI10.1042/cs20260348 (opens in a new tab)PepBankPUB-42024405
Publisher pagePubMedAsk about this study
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Summary

Pulmonary rehabilitation (PR) improves exercise tolerance and dyspnoea in chronic obstructive pulmonary disease (COPD) but does not address the elevated cardiovascular disease (CVD) risk. Vascular dysfunction, an early CVD feature, is driven by oxidative stress-a shared pathogenic mechanism in COPD and CVD. Carnosine, a bioactive dipeptide with antioxidant and pH-buffering properties, may enhance muscle performance and protect against vascular injury. The present study sought to determine whether carnosine supplementation combined with exercise training could modify early CVD features in a preclinical COPD model. Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week). After 8 weeks, blood pressure, exercise capacity, resting heart rate, lung inflammation, systemic oxidative stress, aortic endothelial function, and platelet activation were assessed. CS impaired weight gain, reduced exercise capacity, elevated resting heart rate, and induced airway inflammation (P <0.0001). CS also caused severe endothelial dysfunction and platelet activation (P <0.0001). Exercise alone did not reverse these vascular abnormalities. In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation. Exercise training alone is insufficient to counteract CS-induced vascular injury. Carnosine supplementation provides synergistic vascular protection, highlighting its potential as an adjunct to PR to mitigate oxidative stress-driven CVD risk in COPD.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise preserved endothelial function compared with exercise alone.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise preserved blood vessel function compared with exercise alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseEndothelial function
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Comparator
    Exercise alone
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1 mg/ml in drinking water · drinking water · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    2 context sentences
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise prevented platelet adhesion compared with exercise alone.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise prevented platelet adhesion compared with exercise alone.

    Peptide
    L-carnosine
    Outcome
    DecreasePlatelet adhesion
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Comparator
    Exercise alone
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    1 mg/ml in drinking water · drinking water · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    2 context sentences
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise prevented platelet activation compared with exercise alone.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise prevented platelet activation compared with exercise alone.

    Peptide
    L-carnosine
    Outcome
    DecreasePlatelet activation
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Comparator
    Exercise alone
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    1 mg/ml in drinking water · drinking water · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    2 context sentences
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 04AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise restored weight gain.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise restored weight gain.

    Peptide
    L-carnosine
    Outcome
    IncreaseWeight gain
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    2 context sentences
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 05AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise restored exercise capacity.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise restored exercise capacity.

    Peptide
    L-carnosine
    Outcome
    IncreaseExercise capacity
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Outcome group
    Exercise and physical function · Cardiovascular

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    2 context sentences
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 06AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise restored heart rate.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise restored heart rate.

    Peptide
    L-carnosine
    Outcome
    DecreaseResting heart rate
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    3 context sentences
    Summary · context
    CS impaired weight gain, reduced exercise capacity, elevated resting heart rate, and induced airway inflammation (P <0.0001).
    Summary · context
    Exercise alone did not reverse these vascular abnormalities.
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 07AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In smoke-exposed mice, carnosine plus exercise did not alter airway inflammation.

    In plain wordsIn smoke-exposed mice, carnosine plus exercise did not alter airway inflammation.

    Peptide
    L-carnosine
    Outcome
    No significant changeAirway inflammation
    Study

    mousen: not reported in source

    Cigarette smoke exposure
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    In contrast, carnosine plus exercise restored weight gain, exercise capacity, and heart rate; preserved endothelial function; and prevented platelet adhesion and activation, without altering airway inflammation.
    1 context sentence
    Summary · context
    Male BALB/c mice were exposed to room air or cigarette smoke (CS; 9 cigarettes/day, 5 days/week, 8 weeks) with or without carnosine (1 mg/ml in drinking water) and with or without treadmill exercise training (50% maximal speed; 30 min/day, 5 days/week).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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