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Study · Animal study (in vivo) · mouse · 2007

13 results

Protective effect of orally administered carnosine on bleomycin-induced lung injury.

Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C

American journal of physiology. Lung cellular and molecular physiology12 Jan 2007Cited by 57 (Europe PMC)

PMID17220373 (opens in a new tab)DOI10.1152/ajplung.00283.2006 (opens in a new tab)PepBankPUB-17220373
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced body weight compared with wild-type mice, as worded in the abstract.

    In plain wordsIn mice given bleomycin, carnosine reduced body weight compared with wild-type mice, as the abstract states.

    Peptide
    L-carnosine
    Outcome
    DecreaseBody weight
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    After bleomycin administration, carnosine-treated mice exhibited a reduced degree of lung damage and inflammation compared with wild-type mice, as shown by the reduction of 1) body weight
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In bleomycin-treated mice, carnosine reduced mortality rate compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced mortality compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseMortality rate
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Mortality · Whole body
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    After bleomycin administration, carnosine-treated mice exhibited a reduced degree of lung damage and inflammation compared with wild-type mice, as shown by the reduction of 1) body weight, 2) mortality rate
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung neutrophil infiltration compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung neutrophil infiltration compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseNeutrophil infiltration
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    3) lung infiltration by neutrophils (myeloperoxidase activity and BAL total and differential cell counts)
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung edema compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung swelling compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseLung edema
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    4) lung edema
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced histological lung injury compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung tissue injury compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseHistological lung injury
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    5) histological evidence of lung injury and collagen deposition
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung collagen deposition compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung collagen deposits compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseCollagen deposition
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    5) histological evidence of lung injury and collagen deposition
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung myeloperoxidase immunostaining compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung myeloperoxidase staining compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseMyeloperoxidase immunostaining
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    6) lung myeloperoxidase, TGF-beta, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung TGF-beta immunostaining compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung TGF-beta staining compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseTGF-beta immunostaining
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    6) lung myeloperoxidase, TGF-beta, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung inducible nitric oxide synthase immunostaining compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung inducible nitric oxide synthase staining compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseInducible nitric oxide synthase immunostaining
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    6) lung myeloperoxidase, TGF-beta, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung nitrotyrosine immunostaining compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung nitrotyrosine staining compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseNitrotyrosine immunostaining
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    6) lung myeloperoxidase, TGF-beta, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced lung poly(ADP-ribose) polymerase immunostaining compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced lung poly(ADP-ribose) polymerase staining compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreasePoly(ADP-ribose) polymerase immunostaining
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    6) lung myeloperoxidase, TGF-beta, inducible nitric oxide synthase, nitrotyrosine, and poly(ADP-ribose) polymerase immunostaining
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced BAL TGF-beta levels compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced TGF-beta in lung wash fluid compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseBAL TGF-beta levels
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    7) BAL TGF-beta levels
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In bleomycin-treated mice, carnosine reduced apoptosis compared with wild-type mice.

    In plain wordsIn mice given bleomycin, carnosine reduced cell death compared with wild-type mice.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    bleomycin-induced lung injury
    Comparator
    wild-type mice
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    150 mg/kg daily · oralAs given in this study (mouse).

    Source sentences

    Summary
    8) apoptosis.
    1 context sentence
    Summary · context
    Mice were subjected to intratracheal administration of bleomycin and were assigned to receive carnosine daily by an oral bolus of 150 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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