Skip to content

Study · Animal study (in vivo) · rat · 2025

3 results

Thirty-day oral exposure to acetamiprid induces biochemical and histological alterations in rat pancreas: protective effects of carnosine supplementation.

Benchikh I, Ziani K, Benalia A, Djebbar AA, Argoub H, Khaled MB

Toxicology mechanisms and methods3 Dec 2024Cited by 1 (Europe PMC)

PMID39627014 (opens in a new tab)DOI10.1080/15376516.2024.2435350 (opens in a new tab)PepBankPUB-39627014
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In acetamiprid-exposed rats, carnosine slightly improved elevated lipase secretion.

    In plain wordsIn rats exposed to acetamiprid, carnosine slightly reduced elevated lipase secretion compared with acetamiprid alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseLipase secretion
    Study

    ratn: not reported in source

    Acetamiprid-exposed male Wistar rats
    Comparator
    Acetamiprid alone
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of carnosine led to a slight improvement in the increase of lipase (p ≤ 0.01) and the decrease of amylase (p ≤ 0.001) secretions and prevention of histopathological features induced by acetamiprid.
    1 context sentence
    Summary · context
    This study aimed to investigate the mechanistic toxic effect of oral administration of acetamiprid at 21.7 and 43.4 mg/kg body weight on the histological structure and pancreatic function of male Wistar rats and the potential effect of carnosine in mitigating this toxicity for 30 consecutive days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In acetamiprid-exposed rats, carnosine slightly improved reduced amylase secretion.

    In plain wordsIn rats exposed to acetamiprid, carnosine slightly improved reduced amylase secretion compared with acetamiprid alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseAmylase secretion
    Study

    ratn: not reported in source

    Acetamiprid-exposed male Wistar rats
    Comparator
    Acetamiprid alone
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of carnosine led to a slight improvement in the increase of lipase (p ≤ 0.01) and the decrease of amylase (p ≤ 0.001) secretions and prevention of histopathological features induced by acetamiprid.
    1 context sentence
    Summary · context
    This study aimed to investigate the mechanistic toxic effect of oral administration of acetamiprid at 21.7 and 43.4 mg/kg body weight on the histological structure and pancreatic function of male Wistar rats and the potential effect of carnosine in mitigating this toxicity for 30 consecutive days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, carnosine prevented histopathological features induced by acetamiprid.

    In plain wordsIn rats, carnosine prevented pancreatic tissue changes compared with acetamiprid alone.

    Peptide
    L-carnosine
    Outcome
    DecreasePancreatic histopathology
    Study

    ratn: not reported in source

    Acetamiprid-exposed male Wistar rats
    Comparator
    Acetamiprid alone
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · 30 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Administration of carnosine led to a slight improvement in the increase of lipase (p ≤ 0.01) and the decrease of amylase (p ≤ 0.001) secretions and prevention of histopathological features induced by acetamiprid.
    1 context sentence
    Summary · context
    This study aimed to investigate the mechanistic toxic effect of oral administration of acetamiprid at 21.7 and 43.4 mg/kg body weight on the histological structure and pancreatic function of male Wistar rats and the potential effect of carnosine in mitigating this toxicity for 30 consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.