Skip to content

Study · Non-randomized trial · n = 5 · 2021

4 results

Acute preexercise supplementation of combined carnosine and anserine enhances initial maximal power of Wingate tests in humans.

Blancquaert L, Everaert I, Baguet A, Bex T, Barbaresi S, de Jager S, Lievens E, Stautemas J, De Smet S, Baron G, Gilardoni E, Regazzoni L, Aldini G, Derave W

Journal of applied physiology (Bethesda, Md. : 1985)29 Apr 2021Cited by 8 (Europe PMC)

PMID33914660 (opens in a new tab)DOI10.1152/japplphysiol.00602.2020 (opens in a new tab)PepBankPUB-33914660
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In five subjects, adding carnosine to anserine increased plasma anserine AUC 2.5-fold versus anserine alone.

    In plain wordsAdding carnosine increased blood anserine exposure compared with anserine alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseAnserine bioavailability
    Study

    n = 5

    Comparator
    Anserine alone
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    25 mg/kg · oralAs given in this study (human).

    Measurements

    Anserine AUC increase
    2.5 fold
    ANS + CARN versus ANS

    Source sentences

    Summary
    In vivo bioavailability of plasma anserine was more prominent [2.5-fold increased area under the curve (AUC)] when ANS + CARN versus ANS was ingested.
    1 context sentence
    Summary · context
    Second, five subjects were supplemented with 25 mg/kg anserine or 25 mg/kg of each anserine and carnosine to test in vivo bioavailability.
  2. 02LabIn vitro (cell-free)Pharmacokinetics

    In human plasma, adding carnosine further slowed anserine degradation.

    In plain wordsIn lab tests, adding carnosine slowed anserine breakdown compared with anserine alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseAnserine degradation
    Study

    humann: not reported in source

    Human plasma
    Comparator
    Anserine alone
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro experiments demonstrated slower degradation of anserine versus carnosine, which was further slowed by simultaneously adding carnosine.
    1 context sentence
    Summary · context
    First, in vitro hydrolysis was tested by adding carnosine and anserine to human plasma, alone or in combination.

Studies that did not test the peptide alone2

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 03HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In study A, combined anserine and carnosine increased initial Wingate power versus placebo.

    In plain wordsCombined anserine and carnosine increased initial cycling power compared with placebo.

    Peptide
    L-carnosine
    Outcome
    IncreaseInitial Wingate power in study A
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal

    Measurements

    Power
    12.8 W/kg
    ANS + CARN
    Power
    12.1 W/kg
    placebo
    Power increase
    6%
    versus placebo

    Source sentences

    Summary
    Study A showed significantly higher (+6% ± 11%; P = 0.04) power in the first 5 s of the Wingate test following ANS + CARN (12.8 ± 2.4 W/kg) versus placebo (12.1 ± 2.2 W/kg).
    1 context sentence
    Summary · context
    Third, two double-blind, placebo-controlled, crossover studies investigated the effect of preexercise ANS + CARN (20 mg/kg body wt of each) supplementation on performance during a single all-out Wingate test following 6-min high-intensity cycling (study A)

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 04HumanNot a test of L-carnosine aloneNon-randomized trialEfficacy outcome

    In study B, combined anserine and carnosine increased peak power throughout three Wingate tests versus placebo.

    In plain wordsCombined anserine and carnosine increased peak cycling power compared with placebo.

    Peptide
    L-carnosine
    Outcome
    IncreasePeak Wingate power in study B
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal

    Measurements

    Peak power increase
    3%
    versus placebo
    Peak power
    10.5 W/kg
    ANS + CARN
    Peak power
    10.2 W/kg
    placebo

    Source sentences

    Summary
    Study B demonstrated increased peak power (+3%) throughout three consecutive Wingate tests (ANS + CARN 10.5 ± 0.6 W/kg vs. placebo 10.2 ± 9.9 W/kg).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.