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Study · Randomized controlled trial · n = 50 · 2018

6 results

l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Ghajar A, Aghajan-Nashtaei F, Afarideh M, Mohammadi MR, Akhondzadeh S

Journal of child and adolescent psychopharmacology22 Feb 2018Cited by 19 (Europe PMC)

PMID29469593 (opens in a new tab)DOI10.1089/cap.2017.0157 (opens in a new tab)PepBankPUB-29469593
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In children with ADHD receiving methylphenidate, carnosine showed a significant time-by-treatment interaction for parent-rated total scores versus placebo.

    In plain wordsIn children receiving methylphenidate, parent-rated total scores showed a time-by-treatment interaction with carnosine versus placebo.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedParent ADHD-RS total interaction
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Psychiatric symptoms · Nervous system and cognition
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Using the general linear model repeated measures, significant effect was observed for time × treatment interaction on total and inattention subscales of the Parent ADHD-RS (Greenhouse-Geisser corrected: F = 3.783, df = 1.444, p = 0.041 and F = 4.032, df = 1.600, p = 0.030).
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In children with ADHD receiving methylphenidate, carnosine showed a significant time-by-treatment interaction for parent-rated inattention versus placebo.

    In plain wordsIn children receiving methylphenidate, parent-rated inattention showed a time-by-treatment interaction with carnosine versus placebo.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedParent ADHD-RS inattention interaction
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Psychiatric symptoms · Nervous system and cognition
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Using the general linear model repeated measures, significant effect was observed for time × treatment interaction on total and inattention subscales of the Parent ADHD-RS (Greenhouse-Geisser corrected: F = 3.783, df = 1.444, p = 0.041 and F = 4.032, df = 1.600, p = 0.030).
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In children with ADHD receiving methylphenidate, teacher-rated total score improvement did not differ significantly between carnosine and placebo.

    In plain wordsIn children receiving methylphenidate, teacher-rated total score improvement did not differ significantly between carnosine and placebo.

    Peptide
    L-carnosine
    Outcome
    No significant changeTeacher ADHD-RS total
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Psychiatric symptoms · Nervous system and cognition
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Improvements in the Teacher ADHD-RS were not significantly different between the two groups in total (Greenhouse-Geisser corrected: F = 0.200, df = 1.218, p = 0.705), as well as inattention and hyperactivity subscale scores (p = 0.956 and 0.281, respectively).
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In children with ADHD receiving methylphenidate, teacher-rated inattention improvement did not differ significantly between carnosine and placebo.

    In plain wordsIn children receiving methylphenidate, teacher-rated inattention improvement did not differ significantly between carnosine and placebo.

    Peptide
    L-carnosine
    Outcome
    No significant changeTeacher ADHD-RS inattention
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Psychiatric symptoms · Nervous system and cognition
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Improvements in the Teacher ADHD-RS were not significantly different between the two groups in total (Greenhouse-Geisser corrected: F = 0.200, df = 1.218, p = 0.705), as well as inattention and hyperactivity subscale scores (p = 0.956 and 0.281, respectively).
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In children with ADHD receiving methylphenidate, teacher-rated hyperactivity improvement did not differ significantly between carnosine and placebo.

    In plain wordsIn children receiving methylphenidate, teacher-rated hyperactivity improvement did not differ significantly between carnosine and placebo.

    Peptide
    L-carnosine
    Outcome
    No significant changeTeacher ADHD-RS hyperactivity
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Psychiatric symptoms · Nervous system and cognition
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    Improvements in the Teacher ADHD-RS were not significantly different between the two groups in total (Greenhouse-Geisser corrected: F = 0.200, df = 1.218, p = 0.705), as well as inattention and hyperactivity subscale scores (p = 0.956 and 0.281, respectively).
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.
  6. 06HumanRandomized controlled trialSafety outcome

    In children with ADHD receiving methylphenidate, side effect frequency did not differ significantly between carnosine and placebo.

    In plain wordsIn children receiving methylphenidate, side effect frequency did not differ significantly between carnosine and placebo.

    Peptide
    L-carnosine
    Outcome
    No significant changeSide effect frequency
    Study

    n = 50

    Comparator
    Placebo plus methylphenidate
    Outcome group
    Adverse events · Whole body
    Studied dose
    800 mg/d in two divided doses · 8 weeksAs given in this study (human).

    Source sentences

    Summary
    The frequency of side effects was not significantly different between the two treatment arms.
    3 context sentences
    Summary · context
    This was an 8-week, randomized, double-blind placebo-controlled study.
    Summary · context
    Fifty-six drug-free children and adolescents aged 6-17 years old with a diagnosis of ADHD entered the study.
    Summary · context
    The patients were randomly assigned to l-carnosine (800 mg/d in two divided doses) or placebo plus methylphenidate (0.5-1.5 mg/kg/d) for 8 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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