Effects of l-Carnosine Supplementation on Sleep Disorders and Disease Severity in Autistic Children: A Randomized, Controlled Clinical Trial.

Mehrazad-Saber Z, Kheirouri S, Noorazar SG

Basic & clinical pharmacology & toxicology30 Mar 2018Cited by 43 (Europe PMC)

PMID29430839DOI10.1111/bcpt.12979PepBankPUB-29430839

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In autistic children, carnosine did not significantly change anthropometric indices versus control.
In plain wordsIn autistic children, carnosine did not significantly change body measurements compared with placebo control.
Peptide
L-carnosine
Outcome
No significant changeAnthropometric indices
Study
n = 43
Comparator
placebo control
Outcome group
Body weight · Metabolic and weight
Studied dose
500 mg/day · 2 monthsAs given in this study (human).
Source sentences
Summary
Carnosine supplementation did not change anthropometric indices (p > 0.05) and showed no effect on autism severity (p > 0.05), whereas it significantly reduced sleep duration (p = 0.04), parasomnias (p = 0.02) and total sleep disorders score by 7.59% (p = 0.006) when compared with the control group.
3 context sentences(design, population, supporting numbers)
Summary · context
In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for 2 months, respectively.
Summary · context
Sleep disorders were measured using Children's Sleep Habits Questionnaires.
Summary · context
Gilliam Autism Rating Scale 2 was used to assess the effects of carnosine supplementation on the autism severity.
Report a problemFND-2943083901
02HumanRandomized controlled trialEfficacy outcome
In autistic children, carnosine had no significant effect on autism severity versus control.
In plain wordsIn autistic children, carnosine did not significantly change autism severity compared with placebo control.
Peptide
L-carnosine
Outcome
No significant changeAutism severity
Study
n = 43
Comparator
placebo control
Outcome group
Autism core symptoms · Nervous system and cognition
Studied dose
500 mg/day · 2 monthsAs given in this study (human).
Source sentences
Summary
Carnosine supplementation did not change anthropometric indices (p > 0.05) and showed no effect on autism severity (p > 0.05), whereas it significantly reduced sleep duration (p = 0.04), parasomnias (p = 0.02) and total sleep disorders score by 7.59% (p = 0.006) when compared with the control group.
3 context sentences(design, population, supporting numbers)
Summary · context
In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for 2 months, respectively.
Summary · context
Sleep disorders were measured using Children's Sleep Habits Questionnaires.
Summary · context
Gilliam Autism Rating Scale 2 was used to assess the effects of carnosine supplementation on the autism severity.
Report a problemFND-2943083902
03HumanRandomized controlled trialEfficacy outcome
In autistic children, carnosine significantly reduced the sleep duration subscale score versus control.
In plain wordsIn autistic children, carnosine reduced the sleep duration questionnaire score compared with placebo control.
Peptide
L-carnosine
Outcome
DecreaseSleep duration subscale
Study
n = 43
Comparator
placebo control
Outcome group
Sleep · Sleep
Studied dose
500 mg/day · 2 monthsAs given in this study (human).
Source sentences
Summary
Carnosine supplementation did not change anthropometric indices (p > 0.05) and showed no effect on autism severity (p > 0.05), whereas it significantly reduced sleep duration (p = 0.04), parasomnias (p = 0.02) and total sleep disorders score by 7.59% (p = 0.006) when compared with the control group.
4 context sentences(design, population, supporting numbers)
Summary · context
The results suggest that carnosine supplementation could be effective in improving sleep disturbances, in particular sleep duration and parasomnias subscales.
Summary · context
In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for 2 months, respectively.
Summary · context
Sleep disorders were measured using Children's Sleep Habits Questionnaires.
Summary · context
Gilliam Autism Rating Scale 2 was used to assess the effects of carnosine supplementation on the autism severity.
Report a problemFND-2943083903
04HumanRandomized controlled trialEfficacy outcome
In autistic children, carnosine significantly reduced parasomnias versus control.
In plain wordsIn autistic children, carnosine reduced parasomnias compared with placebo control.
Peptide
L-carnosine
Outcome
DecreaseParasomnias
Study
n = 43
Comparator
placebo control
Outcome group
Sleep · Sleep
Studied dose
500 mg/day · 2 monthsAs given in this study (human).
Source sentences
Summary
Carnosine supplementation did not change anthropometric indices (p > 0.05) and showed no effect on autism severity (p > 0.05), whereas it significantly reduced sleep duration (p = 0.04), parasomnias (p = 0.02) and total sleep disorders score by 7.59% (p = 0.006) when compared with the control group.
3 context sentences(design, population, supporting numbers)
Summary · context
In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for 2 months, respectively.
Summary · context
Sleep disorders were measured using Children's Sleep Habits Questionnaires.
Summary · context
Gilliam Autism Rating Scale 2 was used to assess the effects of carnosine supplementation on the autism severity.
Report a problemFND-2943083904
05HumanRandomized controlled trialEfficacy outcome
In autistic children, carnosine significantly reduced total sleep disorders score by 7.59% versus control.
In plain wordsIn autistic children, carnosine reduced the total sleep disorders score by 7.59% compared with placebo control.
Peptide
L-carnosine
Outcome
DecreaseTotal sleep disorders score
Study
n = 43
Comparator
placebo control
Outcome group
Sleep · Sleep
Studied dose
500 mg/day · 2 monthsAs given in this study (human).
Measurements
Total sleep disorders score reduction
7.59%
versus control
Source sentences
Summary
Carnosine supplementation did not change anthropometric indices (p > 0.05) and showed no effect on autism severity (p > 0.05), whereas it significantly reduced sleep duration (p = 0.04), parasomnias (p = 0.02) and total sleep disorders score by 7.59% (p = 0.006) when compared with the control group.
3 context sentences(design, population, supporting numbers)
Summary · context
In this double-blind, randomized clinical trial, 43 autistic patients (31 boys and 12 girls; aged 4 to 16 years) were divided into two groups of carnosine and control that received 500 mg of carnosine and 500 mg of placebo per day for 2 months, respectively.
Summary · context
Sleep disorders were measured using Children's Sleep Habits Questionnaires.
Summary · context
Gilliam Autism Rating Scale 2 was used to assess the effects of carnosine supplementation on the autism severity.
Report a problemFND-2943083905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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