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Study · Animal study (in vivo) · mouse · 2010

3 results

Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model.

Renner C, Zemitzsch N, Fuchs B, Geiger KD, Hermes M, Hengstler J, Gebhardt R, Meixensberger J, Gaunitz F

Molecular cancer6 Jan 2010Cited by 62 (Europe PMC)

PMID20053283 (opens in a new tab)PMCIDPMC2818694 (opens in a new tab)DOI10.1186/1476-4598-9-2 (opens in a new tab)PepBankPUB-20053283
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Summary

BackgroundIt was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma. In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human cancer therapy.ResultsA mouse model was used to investigate whether tumor growth in vivo can be inhibited by carnosine. Therefore, NIH3T3 fibroblasts, conditionally expressing the human epidermal growth factor receptor 2 (HER2/neu), were implanted into the dorsal skin of nude mice, and tumor growth in treated animals was compared to control mice. In two independent experiments nude mice that received tumor cells received a daily intra peritoneal injection of 500 microl of 1 M carnosine solution. Measurable tumors were detected 12 days after injection. Aggressive tumor growth in control animals, that received a daily intra peritoneal injection of NaCl solution started at day 16 whereas aggressive growth in mice treated with carnosine was delayed, starting around day 19. A significant effect of carnosine on tumor growth was observed up to day 24. Although carnosine was not able to completely prevent tumor growth, a microscopic examination of tumors revealed that those from carnosine treated animals had a significant lower number of mitosis (p < 0.0003) than untreated animals, confirming that carnosine affects proliferation in vivo.ConclusionAs a naturally occurring substance with a high potential to inhibit growth of malignant cells in vivo, carnosine should be considered as a potential anti-cancer drug. Further experiments should be performed in order to understand how carnosine acts at the molecular level.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In tumor-bearing nude mice, carnosine delayed aggressive tumor growth from day 16 in controls to around day 19.

    In plain wordsIn tumor-bearing mice, carnosine delayed aggressive tumor growth compared with saline controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseOnset of aggressive tumor growth
    Study

    mousen: not reported in source

    NIH3T3-HER2/neu tumor-bearing nude mice
    Comparator
    NaCl solution
    Outcome group
    Tumor growth · Cancer
    Studied dose
    500 microl of 1 M carnosine solution daily · intraperitonealAs given in this study (mouse).

    Measurements

    Aggressive growth onset
    16 day
    control
    Aggressive growth onset
    ≈ 19 day
    carnosine

    Source sentences

    Summary
    Aggressive tumor growth in control animals, that received a daily intra peritoneal injection of NaCl solution started at day 16 whereas aggressive growth in mice treated with carnosine was delayed, starting around day 19.
    2 context sentences
    Summary · context
    Therefore, NIH3T3 fibroblasts, conditionally expressing the human epidermal growth factor receptor 2 (HER2/neu), were implanted into the dorsal skin of nude mice, and tumor growth in treated animals was compared to control mice.
    Summary · context
    In two independent experiments nude mice that received tumor cells received a daily intra peritoneal injection of 500 microl of 1 M carnosine solution.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In tumor-bearing nude mice, carnosine significantly inhibited tumor growth up to day 24 without completely preventing growth.

    In plain wordsIn tumor-bearing mice, carnosine reduced tumor growth compared with controls but did not prevent it completely.

    Peptide
    L-carnosine
    Outcome
    DecreaseTumor growth
    Study

    mousen: not reported in source

    NIH3T3-HER2/neu tumor-bearing nude mice
    Comparator
    NaCl solution
    Outcome group
    Tumor growth · Cancer
    Studied dose
    500 microl of 1 M carnosine solution daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    A significant effect of carnosine on tumor growth was observed up to day 24.
    4 context sentences
    Summary · context
    Although carnosine was not able to completely prevent tumor growth,
    Title · context
    Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model.
    Summary · context
    Therefore, NIH3T3 fibroblasts, conditionally expressing the human epidermal growth factor receptor 2 (HER2/neu), were implanted into the dorsal skin of nude mice, and tumor growth in treated animals was compared to control mice.
    Summary · context
    In two independent experiments nude mice that received tumor cells received a daily intra peritoneal injection of 500 microl of 1 M carnosine solution.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In tumor-bearing nude mice, carnosine significantly reduced tumor mitoses compared with untreated animals.

    In plain wordsIn tumor-bearing mice, carnosine reduced dividing tumor cells compared with untreated animals.

    Peptide
    L-carnosine
    Outcome
    DecreaseTumor mitoses
    Study

    mousen: not reported in source

    NIH3T3-HER2/neu tumor-bearing nude mice
    Comparator
    NaCl solution
    Outcome group
    Tumor growth · Cancer
    Studied dose
    500 microl of 1 M carnosine solution daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    a microscopic examination of tumors revealed that those from carnosine treated animals had a significant lower number of mitosis (p < 0.0003) than untreated animals,
    2 context sentences
    Summary · context
    Therefore, NIH3T3 fibroblasts, conditionally expressing the human epidermal growth factor receptor 2 (HER2/neu), were implanted into the dorsal skin of nude mice, and tumor growth in treated animals was compared to control mice.
    Summary · context
    In two independent experiments nude mice that received tumor cells received a daily intra peritoneal injection of 500 microl of 1 M carnosine solution.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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