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Study · Randomized controlled trial · n = 35 · 2025

7 results

Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study.

Perić L, Drenjančević I, Jukić I, Boris A, Šušnjara P, Kolobarić N, Mihaljević Z, Kralik Z, Kralik G, Košević M, Galović O, Stupin A

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme1 Jan 2025Cited by 1 (Europe PMC)

PMID39983097 (opens in a new tab)DOI10.1139/apnm-2024-0458 (opens in a new tab)PepBankPUB-39983097
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male athletes, urate levels were lower with the carnosine-enriched diet than with the control diet.

    In plain wordsIn male athletes, urate levels were lower with the carnosine-enriched diet than with the control diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseUrate levels
    Study

    n = 35

    Comparator
    Control diet
    Outcome group
    Blood biochemical markers · Metabolic and weight
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Following dietary protocol, Controls (n = 16) had substantially higher urate (but still normal) levels than the Carnosine group.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male athletes, microvascular endothelium-independent vasodilation increased after the carnosine-enriched diet.

    In plain wordsIn male athletes, small-vessel dilation increased after the carnosine-enriched diet.

    Peptide
    L-carnosine
    Outcome
    IncreaseMicrovascular endothelium-independent vasodilation
    Study

    n = 19

    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n = 19) following the 3-week dietary protocol.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male athletes, macrovascular endothelium-independent vasodilation increased after the carnosine-enriched diet.

    In plain wordsIn male athletes, large-vessel dilation increased after the carnosine-enriched diet.

    Peptide
    L-carnosine
    Outcome
    IncreaseMacrovascular endothelium-independent vasodilation
    Study

    n = 19

    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n = 19) following the 3-week dietary protocol.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male athletes, diastolic blood pressure decreased after the carnosine-enriched diet.

    In plain wordsIn male athletes, diastolic blood pressure decreased after the carnosine-enriched diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseDiastolic blood pressure
    Study

    n = 19

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n = 19) following the 3-week dietary protocol.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In male athletes, mean arterial blood pressure decreased after the carnosine-enriched diet.

    In plain wordsIn male athletes, mean arterial blood pressure decreased after the carnosine-enriched diet.

    Peptide
    L-carnosine
    Outcome
    DecreaseMean arterial blood pressure
    Study

    n = 19

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Both forearm skin micro- and macrovascular endothelium-independent vasodilation were increased, and diastolic and mean arterial blood pressure (BP) were decreased in Carnosine group (n = 19) following the 3-week dietary protocol.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In male athletes, microvascular post-occlusion reactive hyperemia increased after the carnosine-enriched diet.

    In plain wordsIn male athletes, small-vessel blood flow after temporary occlusion increased after the carnosine-enriched diet.

    Peptide
    L-carnosine
    Outcome
    IncreasePost-occlusion reactive hyperemia
    Study

    n = 19

    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · oral · 3 weeksAs given in this study (human).

    Source sentences

    Summary
    Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.

Studies that did not test the peptide alone1

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 07HumanNot a test of L-carnosine aloneObservational studyOther

    In the carnosine group, increased microvascular response was significantly associated with decreased mean arterial blood pressure.

    In plain wordsIn the carnosine group, improved small-vessel response was linked to lower mean arterial blood pressure.

    Peptide
    L-carnosine
    Outcome
    Not applicableVascular response and blood pressure association
    Study

    n = 19

    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    Microvascular endothelium-dependent response (post-occlusion reactive hyperemia) was increased in the Carnosine group and significantly associated with decreased mean arterial BP level.
    1 context sentence
    Summary · context
    This randomized interventional study aimed to investigate the effect of carnosine-enriched chicken meat consumption on systemic endothelium-dependent and -independent micro- and macrovascular reactivity in thirty-five healthy competitive male athletes.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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