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Study · Animal study (in vivo) · rat · 2011

8 results

Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats.

Riedl E, Pfister F, Braunagel M, Brinkkötter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Krämer BK, Navis G, Hammes HP, Yard B, Koeppel H

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology16 Aug 2011Cited by 88 (Europe PMC)

PMID21865735 (opens in a new tab)DOI10.1159/000331740 (opens in a new tab)PepBankPUB-21865735
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In diabetic rats, carnosine treatment restored kidney carnosine levels.

    In plain wordsIn diabetic rats, carnosine treatment restored kidney carnosine levels compared with diabetic rats without treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseKidney carnosine levels
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Comparator
    Diabetic rats
    Outcome group
    Pharmacokinetics · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment restored carnosine kidney levels,
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine prevented podocyte loss, with numbers 23% higher than in diabetic controls.

    In plain wordsIn diabetic rats, carnosine preserved podocytes compared with diabetic controls.

    Peptide
    L-carnosine
    Outcome
    IncreasePodocyte numbers
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Comparator
    Diabetic rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Measurements

    Podocyte numbers
    23%
    compared to diabetic

    Source sentences

    Summary
    prevented podocytes loss (+23% compared to diabetic, p<0.05)
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine reduced glomerular apoptosis by 34% compared with diabetic controls.

    In plain wordsIn diabetic rats, carnosine reduced glomerular cell death compared with diabetic controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseGlomerular apoptosis
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Comparator
    Diabetic rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Measurements

    Glomerular apoptosis
    −34%
    compared to diabetic

    Source sentences

    Summary
    restrained glomerular apoptosis (-34% compared to diabetic; p<0.05)
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine reduced bax expression by 63% compared with diabetic controls.

    In plain wordsIn diabetic rats, carnosine reduced bax expression compared with diabetic controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseBax expression
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Comparator
    Diabetic rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Measurements

    Bax expression
    −63%
    compared to diabetics

    Source sentences

    Summary
    and reduced expression of bax and cytochrome c (-63% and -54% compared to diabetics, both p<0.05).
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine reduced cytochrome c expression by 54% compared with diabetic controls.

    In plain wordsIn diabetic rats, carnosine reduced cytochrome c expression compared with diabetic controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseCytochrome c expression
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Comparator
    Diabetic rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Measurements

    Cytochrome c expression
    −54%
    compared to diabetics

    Source sentences

    Summary
    and reduced expression of bax and cytochrome c (-63% and -54% compared to diabetics, both p<0.05).
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In all diabetic rats, including those given carnosine, kidney ROS levels were increased.

    In plain wordsIn diabetic rats, kidney ROS levels were increased, including in animals given carnosine.

    Peptide
    L-carnosine
    Outcome
    IncreaseKidney ROS levels
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    In kidneys of all diabetic animals, levels of ROS, AGEs and GlcNAc-modified proteins were increased.
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In all diabetic rats, including those given carnosine, kidney AGEs levels were increased.

    In plain wordsIn diabetic rats, kidney AGEs levels were increased, including in animals given carnosine.

    Peptide
    L-carnosine
    Outcome
    IncreaseKidney AGE levels
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    In kidneys of all diabetic animals, levels of ROS, AGEs and GlcNAc-modified proteins were increased.
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In all diabetic rats, including those given carnosine, kidney GlcNAc-modified proteins levels were increased.

    In plain wordsIn diabetic rats, kidney GlcNAc-modified proteins levels were increased, including in animals given carnosine.

    Peptide
    L-carnosine
    Outcome
    IncreaseKidney GlcNAc-modified proteins
    Study

    ratn: not reported in source

    Streptozotocin-induced diabetic Wistar rats
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    1g/kg BW per day · oral · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    In kidneys of all diabetic animals, levels of ROS, AGEs and GlcNAc-modified proteins were increased.
    1 context sentence
    Summary · context
    We examined the effect of oral L-carnosine administration (1g/kg BW per day) on apoptosis, podocyte loss, oxidative stress, AGEs and hexosamine pathway in kidneys of streptozotocin-induced diabetic Wistar rats after 3 months of diabetes and treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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