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Study · Non-randomized trial · n = 12 · 2014

4 results

Does low serum carnosinase activity favor high-intensity exercise capacity?

Baguet A, Everaert I, Yard B, Peters V, Zschocke J, Zutinic A, De Heer E, Podgórski T, Domaszewska K, Derave W

Journal of applied physiology (Bethesda, Md. : 1985)9 Jan 2014Cited by 21 (Europe PMC)

PMID24408989 (opens in a new tab)DOI10.1152/japplphysiol.01218.2013 (opens in a new tab)PepBankPUB-24408989
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In men receiving acute carnosine, only three subjects developed carnosinemia.

    In plain wordsOnly three men developed measurable circulating carnosine after supplementation.

    Peptide
    L-carnosine
    Outcome
    Not applicableCarnosinemia
    Study

    n = 12

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    20 mg/kg body wtAs given in this study (human).

    Measurements

    Subjects with carnosinemia
    3 subjects
    after acute carnosine supplementation

    Source sentences

    Summary
    Acute carnosine supplementation resulted only in three subjects in carnosinemia.
    1 context sentence
    Summary · context
    In a subsequent double-blind, placebo-controlled, crossover study, 12 men performed a cycling capacity test at 110% maximal power output (CCT 110%) following acute carnosine (20 mg/kg body wt) or placebo supplementation.
  2. 02HumanNon-randomized trialEfficacy outcome

    In men, acute carnosine did not improve cycling capacity versus placebo, including analyses accounting for CN1 content.

    In plain wordsCarnosine did not improve cycling capacity compared with placebo, even after accounting for CN1 content.

    Peptide
    L-carnosine
    Outcome
    No significant changeCycling capacity
    Study

    n = 12

    Comparator
    placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    20 mg/kg body wtAs given in this study (human).

    Source sentences

    Summary
    The CCT 110% performance was not improved after carnosine supplementation, even when accounting for low/high CN1 content.
    1 context sentence
    Summary · context
    In a subsequent double-blind, placebo-controlled, crossover study, 12 men performed a cycling capacity test at 110% maximal power output (CCT 110%) following acute carnosine (20 mg/kg body wt) or placebo supplementation.
  3. 03HumanNon-randomized trialActivity measurement

    In men, carnosine did not change acid-base balance versus placebo, except for resting bicarbonate.

    In plain wordsCarnosine did not change acid-base balance compared with placebo, except for resting bicarbonate.

    Peptide
    L-carnosine
    Outcome
    No significant changeAcid-base balance
    Study

    n = 12

    Comparator
    placebo
    Outcome group
    Electrolyte balance · Whole body
    Studied dose
    20 mg/kg body wtAs given in this study (human).

    Source sentences

    Summary
    No differences were found in acid-base balance, except for elevated resting bicarbonate following carnosine supplementation and in low CN1 subjects.
    1 context sentence
    Summary · context
    In a subsequent double-blind, placebo-controlled, crossover study, 12 men performed a cycling capacity test at 110% maximal power output (CCT 110%) following acute carnosine (20 mg/kg body wt) or placebo supplementation.
  4. 04HumanNon-randomized trialActivity measurement

    In men, resting bicarbonate increased following carnosine supplementation.

    In plain wordsIn men, resting bicarbonate was higher after carnosine supplementation than after placebo.

    Peptide
    L-carnosine
    Outcome
    IncreaseResting bicarbonate
    Study

    n = 12

    Comparator
    placebo
    Outcome group
    Electrolyte balance · Whole body
    Studied dose
    20 mg/kg body wtAs given in this study (human).

    Source sentences

    Summary
    No differences were found in acid-base balance, except for elevated resting bicarbonate following carnosine supplementation and in low CN1 subjects.
    1 context sentence
    Summary · context
    In a subsequent double-blind, placebo-controlled, crossover study, 12 men performed a cycling capacity test at 110% maximal power output (CCT 110%) following acute carnosine (20 mg/kg body wt) or placebo supplementation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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