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Study · Randomized controlled trial · n = 30 · 2016

5 results

Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial.

de Courten B, Jakubova M, de Courten MP, Kukurova IJ, Vallova S, Krumpolec P, Valkovic L, Kurdiova T, Garzon D, Barbaresi S, Teede HJ, Derave W and 4 more

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Krssak M, Aldini G, Ukropec J, Ukropcova B

Obesity (Silver Spring, Md.)4 Apr 2016Cited by 137 (Europe PMC)

PMID27040154 (opens in a new tab)DOI10.1002/oby.21434 (opens in a new tab)PepBankPUB-27040154
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with overweight or obesity, carnosine hampered the increase in fasting insulin compared with placebo.

    In plain wordsIn adults with overweight or obesity, carnosine limited the rise in fasting insulin compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseFasting insulin
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2 g daily · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    An increase in fasting insulin and insulin resistance was hampered in individuals receiving carnosine compared to placebo, and this remained significant after adjustment for age, sex, and change in body weight (P = 0.02, P = 0.04, respectively).
    1 context sentence
    Summary · context
    In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with overweight or obesity, carnosine hampered the increase in insulin resistance compared with placebo.

    In plain wordsIn adults with overweight or obesity, carnosine limited the rise in insulin resistance compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseInsulin resistance
    Study

    n = 30

    Comparator
    Placebo
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2 g daily · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    An increase in fasting insulin and insulin resistance was hampered in individuals receiving carnosine compared to placebo, and this remained significant after adjustment for age, sex, and change in body weight (P = 0.02, P = 0.04, respectively).
    1 context sentence
    Summary · context
    In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks.
  3. 03HumanRandomized controlled trialPharmacokinetics

    In adults with overweight or obesity, urinary carnosine increased after supplementation.

    In plain wordsIn adults with overweight or obesity, urinary carnosine increased after supplementation.

    Peptide
    L-carnosine
    Outcome
    IncreaseUrinary carnosine
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    2 g daily · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Carnosine concentrations increased in urine after supplementation (P < 0.05).
    1 context sentence
    Summary · context
    In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In participants with impaired glucose tolerance, two-hour glucose was lower after carnosine than placebo.

    In plain wordsIn participants with impaired glucose tolerance, glucose at two hours was lower after carnosine than placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseTwo-hour glucose
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2 g daily · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Two-hour glucose and insulin were both lower after carnosine supplementation compared to placebo in individuals with impaired glucose tolerance (P < 0.05).
    1 context sentence
    Summary · context
    In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In participants with impaired glucose tolerance, two-hour insulin was lower after carnosine than placebo.

    In plain wordsIn participants with impaired glucose tolerance, insulin at two hours was lower after carnosine than placebo.

    Peptide
    L-carnosine
    Outcome
    DecreaseTwo-hour insulin
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    2 g daily · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Two-hour glucose and insulin were both lower after carnosine supplementation compared to placebo in individuals with impaired glucose tolerance (P < 0.05).
    1 context sentence
    Summary · context
    In a double-blind randomized pilot trial in nondiabetic individuals with overweight and obesity (age 43 ± 8 years; body mass index 31 ± 4 kg/m(2) ), 15 individuals were randomly assigned to 2 g carnosine daily and 15 individuals to placebo for 12 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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