Skip to content

Study · Animal study (in vivo) · mouse · 2014

6 results

Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice.

Haeri SA, Rajabi H, Fazelipour S, Hosseinimehr SJ

Andrologia12 Nov 2013Cited by 13 (Europe PMC)

PMID24215656 (opens in a new tab)DOI10.1111/and.12193 (opens in a new tab)PepBankPUB-24215656
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated male mice, carnosine reduced TUNEL-positive cell frequency by a factor of 1.8 versus radiation alone.

    In plain wordsIn mice, carnosine reduced testicular cell death compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cells
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with carnosine before irradiation significantly reduced the frequency of TUNEL-positive cells induced by radiation treatment at all doses by reduction factors of 1.8, 2.47 and 2.23 for carnosine at 10, 50 and 100 mg kg(-1) bw, respectively, unlike that observed in the radiation alone group.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated male mice, carnosine reduced TUNEL-positive cell frequency by a factor of 2.47 versus radiation alone.

    In plain wordsIn mice, carnosine reduced testicular cell death compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cells
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with carnosine before irradiation significantly reduced the frequency of TUNEL-positive cells induced by radiation treatment at all doses by reduction factors of 1.8, 2.47 and 2.23 for carnosine at 10, 50 and 100 mg kg(-1) bw, respectively, unlike that observed in the radiation alone group.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated male mice, carnosine reduced TUNEL-positive cell frequency by a factor of 2.23 versus radiation alone.

    In plain wordsIn mice, carnosine reduced testicular cell death compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cells
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with carnosine before irradiation significantly reduced the frequency of TUNEL-positive cells induced by radiation treatment at all doses by reduction factors of 1.8, 2.47 and 2.23 for carnosine at 10, 50 and 100 mg kg(-1) bw, respectively, unlike that observed in the radiation alone group.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, all carnosine doses significantly increased seminiferous epithelial height versus radiation alone.

    In plain wordsIn mice, carnosine increased testicular epithelial height compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseSeminiferous epithelial height
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10, 50 and 100 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with all doses of carnosine significantly augmented seminiferous epithelial height and tubule diameter and also increased the number of germinal cells in comparison to the group treated with radiation only.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, all carnosine doses significantly increased seminiferous tubule diameter versus radiation alone.

    In plain wordsIn mice, carnosine increased testicular tubule diameter compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseSeminiferous tubule diameter
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10, 50 and 100 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with all doses of carnosine significantly augmented seminiferous epithelial height and tubule diameter and also increased the number of germinal cells in comparison to the group treated with radiation only.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, all carnosine doses increased germinal cell numbers versus radiation alone.

    In plain wordsIn mice, carnosine increased germinal cell numbers compared with radiation alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseGerminal cell number
    Study

    micen: not reported in source

    gamma-irradiation testicular injury
    Comparator
    radiation alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10, 50 and 100 mg kg(-1) · intraperitoneal injection · 4 days prior to irradiationAs given in this study (mice).

    Source sentences

    Summary
    Pre-treatment with all doses of carnosine significantly augmented seminiferous epithelial height and tubule diameter and also increased the number of germinal cells in comparison to the group treated with radiation only.
    2 context sentences
    Summary · context
    Carnosine was administered (10, 50 and 100 mg kg(-1) body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy).
    Summary · context
    Apoptosis with the TUNEL assay and histopathological parameters were evaluated 12-h and 14-day post-irradiation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.