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Study · Animal study (in vivo) · rat · 2014

4 results

L-carnosine alters some hemorheologic and lipid peroxidation parameters in nephrectomized rats.

Yapislar H, Taskin E

Medical science monitor : international medical journal of experimental and clinical research11 Mar 2014Cited by 24 (Europe PMC)

PMID24614724 (opens in a new tab)PMCIDPMC3958568 (opens in a new tab)DOI10.12659/msm.890528 (opens in a new tab)PepBankPUB-24614724
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with CKD, carnosine decreased MDA levels.

    In plain wordsIn rats with kidney disease, carnosine lowered MDA compared with saline.

    Peptide
    L-carnosine
    Outcome
    DecreaseMalondialdehyde
    Study

    ratsn = 12

    subtotal nephrectomy-induced CKD
    Comparator
    physiological saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    50 mg/kg · intraperitoneal · 15 daysAs given in this study (rats).

    Source sentences

    Summary
    Carnosine treatment decreased MDA levels, improved RBC (red blood cell) ability to deform, and increased NO levels.
    3 context sentences
    Summary · context
    We used 4-month-old male Sprague-Dawley rats divided into 4 groups of 6 rats each.
    Summary · context
    Carnosine was injected intraperitoneally (i.p.) (50 mg/kg) for 15 days.
    Summary · context
    The control group received the same volume of physiological saline.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats with CKD, carnosine improved red blood cell deformability.

    In plain wordsIn rats with kidney disease, carnosine improved red blood cell flexibility compared with saline.

    Peptide
    L-carnosine
    Outcome
    IncreaseRBC deformability
    Study

    ratsn = 12

    subtotal nephrectomy-induced CKD
    Comparator
    physiological saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    50 mg/kg · intraperitoneal · 15 daysAs given in this study (rats).

    Source sentences

    Summary
    Carnosine treatment decreased MDA levels, improved RBC (red blood cell) ability to deform, and increased NO levels.
    3 context sentences
    Summary · context
    We used 4-month-old male Sprague-Dawley rats divided into 4 groups of 6 rats each.
    Summary · context
    Carnosine was injected intraperitoneally (i.p.) (50 mg/kg) for 15 days.
    Summary · context
    The control group received the same volume of physiological saline.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with CKD, carnosine increased nitric oxide levels.

    In plain wordsIn rats with kidney disease, carnosine increased nitric oxide compared with saline.

    Peptide
    L-carnosine
    Outcome
    IncreaseNitric oxide
    Study

    ratsn = 12

    subtotal nephrectomy-induced CKD
    Comparator
    physiological saline
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    50 mg/kg · intraperitoneal · 15 daysAs given in this study (rats).

    Source sentences

    Summary
    Carnosine treatment decreased MDA levels, improved RBC (red blood cell) ability to deform, and increased NO levels.
    3 context sentences
    Summary · context
    We used 4-month-old male Sprague-Dawley rats divided into 4 groups of 6 rats each.
    Summary · context
    Carnosine was injected intraperitoneally (i.p.) (50 mg/kg) for 15 days.
    Summary · context
    The control group received the same volume of physiological saline.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with CKD, carnosine did not affect blood pressure.

    In plain wordsIn rats with kidney disease, carnosine did not affect blood pressure compared with saline.

    Peptide
    L-carnosine
    Outcome
    No significant changeBlood pressure
    Study

    ratsn = 12

    subtotal nephrectomy-induced CKD
    Comparator
    physiological saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    50 mg/kg · intraperitoneal · 15 daysAs given in this study (rats).

    Source sentences

    Summary
    However, carnosine did not affect blood pressure levels in these rats.
    3 context sentences
    Summary · context
    We used 4-month-old male Sprague-Dawley rats divided into 4 groups of 6 rats each.
    Summary · context
    Carnosine was injected intraperitoneally (i.p.) (50 mg/kg) for 15 days.
    Summary · context
    The control group received the same volume of physiological saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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