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Study · Animal study (in vivo) · rat · 2009

4 results

Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats.

Pekcetin C, Kiray M, Ergur BU, Tugyan K, Bagriyanik HA, Erbil G, Baykara B, Camsari UM

Acta biologica Hungarica1 Jun 2009Cited by 42 (Europe PMC)

PMID19584023 (opens in a new tab)DOI10.1556/abiol.60.2009.2.1 (opens in a new tab)PepBankPUB-19584023
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic rat brains, carnosine significantly decreased lipid peroxidation.

    In plain wordsIn rats with brain ischemia, carnosine reduced lipid peroxidation compared with the ischemia-induction group.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain lipid peroxidation
    Study

    ratn: not reported in source

    transient cerebral ischemia
    Comparator
    ischemia-induction group
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment elicited a significant decrease in lipid peroxidation and increase in antioxidant enzyme activities in ischemic rat brains.
    1 context sentence
    Summary · context
    Transient ischemia was induced by occlusion of right common carotid artery of rats for 30 min and reperfusion for 24 h or 1 week. Rats received intraperitoneal injection of 250 mg/kg carnosine or saline 30 min prior to experiment.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ischemic rat brains, carnosine significantly increased antioxidant enzyme activities.

    In plain wordsIn rats with brain ischemia, carnosine increased antioxidant enzyme activities compared with the ischemia-induction group.

    Peptide
    L-carnosine
    Outcome
    IncreaseAntioxidant enzyme activities
    Study

    ratn: not reported in source

    transient cerebral ischemia
    Comparator
    ischemia-induction group
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment elicited a significant decrease in lipid peroxidation and increase in antioxidant enzyme activities in ischemic rat brains.
    1 context sentence
    Summary · context
    Transient ischemia was induced by occlusion of right common carotid artery of rats for 30 min and reperfusion for 24 h or 1 week. Rats received intraperitoneal injection of 250 mg/kg carnosine or saline 30 min prior to experiment.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transient cerebral ischemia, carnosine significantly decreased TUNEL-positive cells versus the ischemia-induction group.

    In plain wordsIn rats, carnosine reduced TUNEL-positive cells compared with the ischemia-induction group.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cells
    Study

    ratn: not reported in source

    transient cerebral ischemia
    Comparator
    ischemia-induction group
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The number of TUNEL-positive cells was decreased significantly in carnosine-treated group when compared with the ischemia-induction group.
    1 context sentence
    Summary · context
    Transient ischemia was induced by occlusion of right common carotid artery of rats for 30 min and reperfusion for 24 h or 1 week. Rats received intraperitoneal injection of 250 mg/kg carnosine or saline 30 min prior to experiment.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transient cerebral ischemia, carnosine did not significantly protect against spatial learning deficits.

    In plain wordsIn rats, carnosine did not significantly reduce spatial learning deficits compared with the ischemia-induction group.

    Peptide
    L-carnosine
    Outcome
    No significant changeSpatial learning deficits
    Study

    ratn: not reported in source

    transient cerebral ischemia
    Comparator
    ischemia-induction group
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    250 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment did not provide significant protection from ischemia induced deficits in spatial learning.
    1 context sentence
    Summary · context
    Transient ischemia was induced by occlusion of right common carotid artery of rats for 30 min and reperfusion for 24 h or 1 week. Rats received intraperitoneal injection of 250 mg/kg carnosine or saline 30 min prior to experiment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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