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Study · Not a test of the peptide alone · 2016

5 results

Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People.

Hisatsune T, Kaneko J, Kurashige H, Cao Y, Satsu H, Totsuka M, Katakura Y, Imabayashi E, Matsuda H

Journal of Alzheimer's disease : JAD1 Jan 2016Cited by 89 (Europe PMC)

PMID26682691 (opens in a new tab)PMCIDPMC4927867 (opens in a new tab)DOI10.3233/jad-150767 (opens in a new tab)PepBankPUB-26682691
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 01HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation significantly preserved delayed recall verbal memory versus placebo.

    In plain wordsIn elderly volunteers, the anserine/carnosine combination preserved delayed verbal recall compared with placebo.

    Peptide
    L-carnosine
    Outcome
    Not applicableDelayed recall verbal memory
    Study

    n = 39

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    Among the tests, delayed recall verbal memory assessed by the Wechsler Memory Scale-Logical Memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0128).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio.
    Summary · context
    The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months.
    Summary · context
    Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 02HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation suppressed age-related posterior cingulate cortex blood flow decline versus placebo.

    In plain wordsIn elderly volunteers, the combination reduced the age-related decline in posterior brain blood flow compared with placebo.

    Peptide
    L-carnosine
    Outcome
    DecreasePosterior cingulate cortex blood flow decline
    Study

    n = 39

    Comparator
    Placebo
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    MRI analysis using arterial spin labeling showed a suppression in the age-related decline in brain blood flow in the posterior cingulate cortex area in the ACS group, compared to the placebo group (p = 0.0248).
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio.
    Summary · context
    The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months.
    Summary · context
    Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 03HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation decreased CCL-2 secretion.

    In plain wordsIn elderly volunteers, the anserine/carnosine combination decreased CCL-2 secretion.

    Peptide
    L-carnosine
    Outcome
    DecreaseCCL-2 secretion
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group.
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio.
    Summary · context
    The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months.
    Summary · context
    Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 04HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In elderly volunteers, anserine/carnosine supplementation decreased IL-8 secretion.

    In plain wordsIn elderly volunteers, the anserine/carnosine combination decreased IL-8 secretion.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-8 secretion
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group.
    3 context sentences
    Summary · context
    In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio.
    Summary · context
    The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months.
    Summary · context
    Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  5. 05HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome

    In another randomized trial, anserine/carnosine supplementation significantly preserved delayed recall verbal memory versus placebo.

    In plain wordsIn another trial, the anserine/carnosine combination preserved delayed verbal recall compared with placebo.

    Peptide
    L-carnosine
    Outcome
    Not applicableDelayed recall verbal memory in another trial
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In another randomized controlled trial, delayed recall verbal memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0202).

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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