Effects of central injection of L-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.

Tanida M, Gotoh H, Taniguchi H, Otani H, Shen J, Nakamura T, Tsuruoka N, Kiso Y, Okumura N, Nagai K

Regulatory peptides21 Jun 2007Cited by 27 (Europe PMC)

PMID17628717DOI10.1016/j.regpep.2007.06.001PepBankPUB-17628717

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats, low-dose L‑carnosine significantly suppressed sympathetic nerve activity to brown adipose tissue.
In plain wordsIn rats, low-dose L‑carnosine significantly reduced sympathetic nerve activity to brown fat.
Peptide
L-carnosine
Outcome
DecreaseBAT sympathetic nerve activity at low dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.01 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
We found that injection of a low dose of L-carnosine (0.01 microg) suppressed BAT-SNA significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871701
02AnimalAnimal study (in vivo)Mechanism
In rats, high-dose L‑carnosine significantly elevated sympathetic nerve activity to brown adipose tissue.
In plain wordsIn rats, high-dose L‑carnosine significantly increased sympathetic nerve activity to brown fat.
Peptide
L-carnosine
Outcome
IncreaseBAT sympathetic nerve activity at high dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Conversely, a high dose (100 microg) of L-carnosine significantly elevated BAT-SNA.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871702
03AnimalAnimal study (in vivo)Mechanism
In rats during the light period, low-dose L‑carnosine suppressed brown adipose tissue temperature.
In plain wordsIn rats during the light period, low-dose L‑carnosine reduced brown fat temperature.
Peptide
L-carnosine
Outcome
DecreaseBAT temperature in light period at low dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
0.01 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
We found that injection of a low dose of L-carnosine (0.01 microg) suppressed BAT-SNA significantly.
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871703
04AnimalAnimal study (in vivo)Mechanism
In rats during the light period, low-dose L‑carnosine suppressed body temperature.
In plain wordsIn rats during the light period, low-dose L‑carnosine reduced body temperature.
Peptide
L-carnosine
Outcome
DecreaseBody temperature in light period at low dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
0.01 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
We found that injection of a low dose of L-carnosine (0.01 microg) suppressed BAT-SNA significantly.
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871704
05AnimalAnimal study (in vivo)Mechanism
In rats during the light period, high-dose L‑carnosine elevated brown adipose tissue temperature.
In plain wordsIn rats during the light period, high-dose L‑carnosine increased brown fat temperature.
Peptide
L-carnosine
Outcome
IncreaseBAT temperature in light period at high dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
100 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Conversely, a high dose (100 microg) of L-carnosine significantly elevated BAT-SNA.
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871705
06AnimalAnimal study (in vivo)Mechanism
In rats during the light period, high-dose L‑carnosine elevated body temperature.
In plain wordsIn rats during the light period, high-dose L‑carnosine increased body temperature.
Peptide
L-carnosine
Outcome
IncreaseBody temperature in light period at high dose
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
100 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Conversely, a high dose (100 microg) of L-carnosine significantly elevated BAT-SNA.
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871706
07AnimalAnimal study (in vivo)Mechanism
In rats during the dark period, L‑carnosine left brown adipose tissue temperature unchanged.
In plain wordsIn rats during the dark period, L‑carnosine did not change brown fat temperature.
Peptide
L-carnosine
Outcome
No significant changeBAT temperature in dark period
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
Dose not stated · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871707
08AnimalAnimal study (in vivo)Mechanism
In rats during the dark period, L‑carnosine left body temperature unchanged.
In plain wordsIn rats during the dark period, L‑carnosine did not change body temperature.
Peptide
L-carnosine
Outcome
No significant changeBody temperature in dark period
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
Dose not stated · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
In the light period (14:00), brown adipose tissue temperature (BAT-T) and BT were suppressed after low and elevated after high dose injection of L-carnosine whereas in the dark period (2:00), these parameters remained unchanged with L-carnosine treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871708
09AnimalAnimal study (in vivo)Mechanism
In rats with bilateral SCN lesions, the effects of low- and high-dose L‑carnosine on BAT sympathetic nerve activity were abolished.
In plain wordsIn rats with bilateral SCN lesions, low- and high-dose L‑carnosine no longer affected sympathetic nerve activity to brown fat.
Peptide
L-carnosine
Outcome
No significant changeBAT sympathetic nerve activity after SCN lesions
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of low and high doses of L-carnosine on BAT-SNA, BAT-T and BT.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871709
10AnimalAnimal study (in vivo)Mechanism
In rats with bilateral SCN lesions, the effects of low- and high-dose L‑carnosine on brown adipose tissue temperature were abolished.
In plain wordsIn rats with bilateral SCN lesions, low- and high-dose L‑carnosine no longer affected brown fat temperature.
Peptide
L-carnosine
Outcome
No significant changeBAT temperature after SCN lesions
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
Dose not stated · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of low and high doses of L-carnosine on BAT-SNA, BAT-T and BT.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871710
11AnimalAnimal study (in vivo)Mechanism
In rats with bilateral SCN lesions, the effects of low- and high-dose L‑carnosine on body temperature were abolished.
In plain wordsIn rats with bilateral SCN lesions, low- and high-dose L‑carnosine no longer affected body temperature.
Peptide
L-carnosine
Outcome
No significant changeBody temperature after SCN lesions
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Body temperature · Nervous system and cognition
Studied dose
Dose not stated · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of low and high doses of L-carnosine on BAT-SNA, BAT-T and BT.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871711
12AnimalAnimal study (in vivo)Mechanism
In rats, high-dose L‑carnosine altered c-Fos induction in the SCN.
In plain wordsIn rats, high-dose L‑carnosine changed c-Fos induction in the SCN.
Peptide
L-carnosine
Outcome
Direction not reportedSCN c-Fos induction
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Furthermore, high dose treatment with L-carnosine altered c-Fos induction in the SCN and the PVN.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871712
13AnimalAnimal study (in vivo)Mechanism
In rats, high-dose L‑carnosine altered c-Fos induction in the PVN.
In plain wordsIn rats, high-dose L‑carnosine changed c-Fos induction in the PVN.
Peptide
L-carnosine
Outcome
Direction not reportedPVN c-Fos induction
Study
ratn: not reported in source
urethane-anesthetized rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
100 microg · intralateral cerebral ventricular injectionAs given in this study (rat).
Source sentences
Summary
Furthermore, high dose treatment with L-carnosine altered c-Fos induction in the SCN and the PVN.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, using urethane-anesthetized rats, we examined the effects of intralateral cerebral ventricular (LCV) injection of various doses of L-carnosine on neural activity innervating brown adipose tissue (BAT-SNA) and body temperature (BT).
Report a problemFND-1762871713

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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