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Study · Animal study (in vivo) · chicken · 2024

10 results

The effect of gut microbiota-derived carnosine on mucosal integrity and immunity in broiler chickens challenged with Eimeria maxima.

Park I, Nam H, Lee Y, Wickramasuriya SS, Smith AH, Rehberger TG, Lillehoj HS

Poultry science9 May 2024Cited by 4 (Europe PMC)

PMID38848630 (opens in a new tab)PMCIDPMC11214313 (opens in a new tab)DOI10.1016/j.psj.2024.103837 (opens in a new tab)PepBankPUB-38848630
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In E. maxima-infected chickens, dietary carnosine increased body weight.

    In plain wordsIn infected chickens, dietary carnosine increased body weight.

    Peptide
    L-carnosine
    Outcome
    IncreaseBody weight
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.0 or 10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    In vivo feeding studies showed that dietary carnosine increased BW and ADG of chickens in E. maxima-infected groups and reduced the jejunal lesion score and fecal oocyst shedding in HCS group.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In E. maxima-infected chickens, dietary carnosine increased average daily gain.

    In plain wordsIn infected chickens, dietary carnosine increased average daily weight gain.

    Peptide
    L-carnosine
    Outcome
    IncreaseAverage daily gain
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.0 or 10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    In vivo feeding studies showed that dietary carnosine increased BW and ADG of chickens in E. maxima-infected groups and reduced the jejunal lesion score and fecal oocyst shedding in HCS group.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In E. maxima-infected chickens, high-dose dietary carnosine reduced jejunal lesion scores.

    In plain wordsIn infected chickens, high-dose dietary carnosine reduced intestinal lesion scores.

    Peptide
    L-carnosine
    Outcome
    DecreaseJejunal lesion score
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    In vivo feeding studies showed that dietary carnosine increased BW and ADG of chickens in E. maxima-infected groups and reduced the jejunal lesion score and fecal oocyst shedding in HCS group.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In E. maxima-infected chickens, high-dose dietary carnosine reduced fecal oocyst shedding.

    In plain wordsIn infected chickens, high-dose dietary carnosine reduced parasite oocysts shed in feces.

    Peptide
    L-carnosine
    Outcome
    DecreaseFecal oocyst shedding
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    In vivo feeding studies showed that dietary carnosine increased BW and ADG of chickens in E. maxima-infected groups and reduced the jejunal lesion score and fecal oocyst shedding in HCS group.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In infected chickens, high-dose carnosine suppressed jejunal IL-1β expression compared with infected basal-diet controls.

    In plain wordsIn infected chickens, high-dose carnosine lowered intestinal IL-1β expression compared with infected controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseJejunal IL-1beta expression
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Comparator
    Infected chickens on basal diet
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    Jejunal IL-1β, IL-8, and IFN-γ expression were suppressed in the HCS group compared to PC.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In infected chickens, high-dose carnosine suppressed jejunal IL-8 expression compared with infected basal-diet controls.

    In plain wordsIn infected chickens, high-dose carnosine lowered intestinal IL-8 expression compared with infected controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseJejunal IL-8 expression
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Comparator
    Infected chickens on basal diet
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    Jejunal IL-1β, IL-8, and IFN-γ expression were suppressed in the HCS group compared to PC.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In infected chickens, high-dose carnosine suppressed jejunal IFN-γ expression compared with infected basal-diet controls.

    In plain wordsIn infected chickens, high-dose carnosine lowered intestinal IFN-γ expression compared with infected controls.

    Peptide
    L-carnosine
    Outcome
    DecreaseJejunal IFN-gamma expression
    Study

    chickenn: not reported in source

    Eimeria maxima-infected broiler chickens
    Comparator
    Infected chickens on basal diet
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    10.0 mg/kg feed · dietaryAs given in this study (chicken).

    Source sentences

    Summary
    Jejunal IL-1β, IL-8, and IFN-γ expression were suppressed in the HCS group compared to PC.
    2 context sentences
    Summary · context
    One hundred and twenty male broiler chickens (0-day-old) were allocated into 4 treatment groups: 1) basal diet without infection (NC), 2) basal diet with E. maxima infection (PC), 3) carnosine at 10.0 mg/kg feed with PC (HCS), and 4) carnosine at 1.0 mg/kg feed with PC (LCS).
    Summary · context
    All groups except NC were orally infected with E. maxima on d 14.
  8. 08LabIn vitro (cells)Mechanism

    In chicken macrophage cells, carnosine significantly reduced IL-1β gene expression after LPS stimulation.

    In plain wordsIn cells from chickens, carnosine reduced IL-1β gene expression after inflammatory stimulation.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-1beta gene expression
    Study

    chickenn: not reported in source

    LPS-stimulated chicken macrophage cell line
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    0.1, 1.0, and 10.0 µg · 18 hAs given in this study (chicken).

    Source sentences

    Summary
    In vitro, carnosine treatment significantly decreased IL-1β gene expression in CMC following LPS stimulation.
    2 context sentences
    Summary · context
    Cells to be tested were seeded in 24-well plates and treated with carnosine at 4 different concentrations (0.1, 1.0, and 10.0 µg).
    Summary · context
    After 18 h of incubation, cells were harvested to measure gene expression of proinflammatory cytokines in CMC, tight junction (TJ) proteins in IECs, and muscle cell growth markers in QMCs and PMCs.
  9. 09LabIn vitro (cells)Mechanism

    In chicken intestinal epithelial cells, carnosine increased claudin-1 expression in the reported HCS setting.

    In plain wordsIn chicken intestinal cells, carnosine increased claudin-1 expression in the reported HCS setting.

    Peptide
    L-carnosine
    Outcome
    IncreaseClaudin-1 expression
    Study

    chickenn: not reported in source

    Chicken intestinal epithelial cells
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of claudin-1 and occludin in IECs were also increased in HCS following carnosine treatment.
  10. 10LabIn vitro (cells)Mechanism

    In chicken intestinal epithelial cells, carnosine increased occludin expression in the reported HCS setting.

    In plain wordsIn chicken intestinal cells, carnosine increased occludin expression in the reported HCS setting.

    Peptide
    L-carnosine
    Outcome
    IncreaseOccludin expression
    Study

    chickenn: not reported in source

    Chicken intestinal epithelial cells
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The expression levels of claudin-1 and occludin in IECs were also increased in HCS following carnosine treatment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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