In rats, carnosine reduced cisplatin-induced pathological changes in kidney tissue.
In plain wordsIn rats, carnosine reduced kidney tissue damage compared with cisplatin treatment alone.
- Peptide
- L-carnosine
- Outcome
- DecreaseKidney pathological changes
- Study
ratn = 12
cisplatin-induced nephrotoxicity in male Albino Wistar rats- Comparator
- cisplatin-treated rats
- Outcome group
- Kidney function · Kidney and urinary
- Studied dose
- 10 mg/kgAs given in this study (rat).
Source sentences
Carnosine reduced these pathological changes and counteracted the deleterious effects of cisplatin.
3 context sentences(design, population, supporting numbers)
Marked elevation of kidney weight and reduced body weight and pathological changes in kidney tissues were also observed in Cisplatin-treated rats.
24 male Albino Wistar rats, were randomly divided into four groups (n=6).
Group I remains untreated; Group II received Cisplatin (3 mg / kg) for 5 alternate days; Group III received Carnosine (10 mg / kg) for consecutive 10 days; Group IV received Carnosine (10 mg / kg) before administration of Cisplatin (3 mg / kg).