Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans.

Everaert I, Taes Y, De Heer E, Baelde H, Zutinic A, Yard B, Sauerhöfer S, Vanhee L, Delanghe J, Aldini G, Derave W

American journal of physiology. Renal physiology11 Apr 2012Cited by 72 (Europe PMC)

PMID22496410DOI10.1152/ajprenal.00084.2012PepBankPUB-22496410

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. 1 result from people.

01HumanNon-randomized trialPharmacokinetics
After carnosine ingestion, 8 of 25 healthy subjects showed a measurable plasma carnosine increase up to 1 h.
In plain wordsAfter carnosine ingestion, 8 of 25 healthy people had measurable increases in blood carnosine for up to 1 h.
Peptide
L-carnosine
Outcome
IncreaseMeasurable plasma carnosine increase
Study
n = 25
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
60 mg/kg body wt · oralAs given in this study (human).
Measurements
Responders
8 subjects
25 subjects
Source sentences
Summary
Upon carnosine ingestion, 8 of the 25 subjects (responders) displayed a measurable increase in plasma carnosine up to 1 h after supplementation.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
Report a problemFND-2249641001

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

02HumanNot a test of L-carnosine aloneObservational studyPharmacokinetics
After carnosine ingestion, nonresponders had approximately twofold higher plasma carnosinase protein content than responders.
In plain wordsAfter carnosine ingestion, people without measurable blood increases had higher carnosinase protein content than responders.
Peptide
L-carnosine
Outcome
IncreaseCarnosinase protein content by response
Study
n = 25
Comparator
Responders
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Carnosinase protein content ratio
≈ 2 fold
nonresponders versus responders
Source sentences
Summary
Subjects with no measurable increment in plasma carnosine (nonresponders) had ∼2-fold higher plasma carnosinase protein content and ∼1.5-fold higher activity compared with responders.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2249641002
03HumanNot a test of L-carnosine aloneObservational studyPharmacokinetics
After carnosine ingestion, nonresponders had approximately 1.5-fold higher plasma carnosinase activity than responders.
In plain wordsAfter carnosine ingestion, people without measurable blood increases had higher carnosinase activity than responders.
Peptide
L-carnosine
Outcome
IncreaseCarnosinase activity by response
Study
n = 25
Comparator
Responders
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Carnosinase activity ratio
≈ 1.5 fold
nonresponders versus responders
Source sentences
Summary
Subjects with no measurable increment in plasma carnosine (nonresponders) had ∼2-fold higher plasma carnosinase protein content and ∼1.5-fold higher activity compared with responders.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2249641003
04HumanNot a test of L-carnosine aloneObservational studyPharmacokinetics
After carnosine ingestion, urinary carnosine recovery was 2.6-fold higher in responders than nonresponders.
In plain wordsAfter carnosine ingestion, responders excreted 2.6-fold more carnosine in urine than nonresponders.
Peptide
L-carnosine
Outcome
IncreaseUrinary carnosine recovery
Study
n = 25
Comparator
Nonresponders
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Urinary recovery ratio
2.6 fold
responders versus nonresponders
Source sentences
Summary
Urinary carnosine recovery was 2.6-fold higher in responders versus nonresponders and was negatively dependent on both the activity and protein content of the plasma carnosinase enzyme.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2249641004
05HumanNot a test of L-carnosine aloneObservational studyPharmacokinetics
After carnosine ingestion, urinary carnosine recovery was negatively associated with plasma carnosinase activity.
In plain wordsAfter carnosine ingestion, higher carnosinase activity was linked to lower urinary carnosine recovery.
Peptide
L-carnosine
Outcome
DecreaseUrinary recovery association with carnosinase activity
Study
n = 25
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Urinary carnosine recovery was 2.6-fold higher in responders versus nonresponders and was negatively dependent on both the activity and protein content of the plasma carnosinase enzyme.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2249641005
06HumanNot a test of L-carnosine aloneObservational studyPharmacokinetics
After carnosine ingestion, urinary carnosine recovery was negatively associated with plasma carnosinase protein content.
In plain wordsAfter carnosine ingestion, higher carnosinase protein content was linked to lower urinary carnosine recovery.
Peptide
L-carnosine
Outcome
DecreaseUrinary recovery association with carnosinase protein content
Study
n = 25
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Urinary carnosine recovery was 2.6-fold higher in responders versus nonresponders and was negatively dependent on both the activity and protein content of the plasma carnosinase enzyme.
1 context sentence(design, population, supporting numbers)
Summary · context
Blood and urine were sampled in 25 healthy subjects after acute supplementation with 60 mg/kg body wt carnosine.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2249641006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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