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Study · Animal study (in vivo) · rat · 2020

8 results

[The therapeutic effect of carnosine combined with dexamethasone in the lung injury of seawater-drowning].

Han LY, Gao YH, Yu GL, Shi Y, Li WP, Wang ZQ, Li YJ, Jin FG

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases1 Sept 2020

PMID32894911 (opens in a new tab)DOI10.3760/cma.j.cn112147-20191028-00717 (opens in a new tab)PepBankPUB-32894911
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with seawater inhalation injury, carnosine alone alleviated acute lung injury compared with untreated injury.

    In plain wordsIn rats, carnosine alone reduced lung injury compared with untreated seawater injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseAcute lung injury with carnosine alone
    Study

    ratn = 16

    SD rats with seawater inhalation lung injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with RS group, the treatment alleviated acute lung injury and decreased the expression level of SOD in RSD, RSC and RSDC groups (P<0.01).
    1 context sentence
    Summary · context
    The in vivo experiments with SD rats were randomly divided into 5 groups (n=8 each):
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with seawater inhalation injury, carnosine alone decreased SOD expression compared with untreated injury.

    In plain wordsIn rats, carnosine alone reduced SOD expression compared with untreated seawater injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseSOD with carnosine alone
    Study

    ratn = 16

    SD rats with seawater inhalation lung injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with RS group, the treatment alleviated acute lung injury and decreased the expression level of SOD in RSD, RSC and RSDC groups (P<0.01).
    1 context sentence
    Summary · context
    The in vivo experiments with SD rats were randomly divided into 5 groups (n=8 each):
  3. 03LabIn vitro (cells)Efficacy outcome

    In A549 cells with seawater injury, carnosine alone reduced apoptosis to 70.9%.

    In plain wordsIn cells with seawater injury, carnosine alone reduced apoptosis compared with untreated injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptosis with carnosine alone
    Study

    humann: not reported in source

    A549 cells with seawater injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After drug protection, apoptosis was reduced in S+D group, S+C group and S+D+C group, with apoptosis rates of 65.4%, 70.9% and 42.6%, respectively.
    1 context sentence
    Summary · context
    The in vitro experiments with A549 cells were divided into 5 groups: blank control group (C), seawater injury group (S),

Studies that did not test the peptide alone5

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 04AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome

    In rats with seawater inhalation injury, dexamethasone plus carnosine alleviated acute lung injury compared with untreated injury.

    In plain wordsIn rats, dexamethasone plus carnosine reduced lung injury compared with untreated seawater injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseAcute lung injury with combination
    Study

    ratn = 16

    SD rats with seawater inhalation lung injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Lung injury and fibrosis · Respiratory

    Source sentences

    Summary
    Compared with RS group, the treatment alleviated acute lung injury and decreased the expression level of SOD in RSD, RSC and RSDC groups (P<0.01).
    1 context sentence
    Summary · context
    The in vivo experiments with SD rats were randomly divided into 5 groups (n=8 each):

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 05AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Mechanism

    In rats with seawater inhalation injury, dexamethasone plus carnosine decreased SOD expression compared with untreated injury.

    In plain wordsIn rats, dexamethasone plus carnosine reduced SOD expression compared with untreated seawater injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseSOD with combination
    Study

    ratn = 16

    SD rats with seawater inhalation lung injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    Compared with RS group, the treatment alleviated acute lung injury and decreased the expression level of SOD in RSD, RSC and RSDC groups (P<0.01).
    1 context sentence
    Summary · context
    The in vivo experiments with SD rats were randomly divided into 5 groups (n=8 each):

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  3. 06LabNot a test of L-carnosine aloneIn vitro (cells)Efficacy outcome

    In A549 cells with seawater injury, dexamethasone plus carnosine reduced apoptosis to 42.6%.

    In plain wordsIn cells with seawater injury, dexamethasone plus carnosine reduced apoptosis compared with untreated injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptosis with combination
    Study

    humann: not reported in source

    A549 cells with seawater injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Cell viability and death · Respiratory

    Source sentences

    Summary
    After drug protection, apoptosis was reduced in S+D group, S+C group and S+D+C group, with apoptosis rates of 65.4%, 70.9% and 42.6%, respectively.
    1 context sentence
    Summary · context
    The in vitro experiments with A549 cells were divided into 5 groups: blank control group (C), seawater injury group (S),

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  4. 07LabNot a test of L-carnosine aloneIn vitro (cells)Efficacy outcome

    In A549 cells with seawater injury, TNF-α decreased with dexamethasone plus carnosine.

    In plain wordsIn cells with seawater injury, dexamethasone plus carnosine reduced TNF-α compared with untreated injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseTNF-α with combination
    Study

    humann: not reported in source

    A549 cells with seawater injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    The contents of TNF-α and IL-6 also decreased in the S+D+C group (P<0.01).
    1 context sentence
    Summary · context
    The in vitro experiments with A549 cells were divided into 5 groups: blank control group (C), seawater injury group (S),

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  5. 08LabNot a test of L-carnosine aloneIn vitro (cells)Efficacy outcome

    In A549 cells with seawater injury, IL-6 decreased with dexamethasone plus carnosine.

    In plain wordsIn cells with seawater injury, dexamethasone plus carnosine reduced IL-6 compared with untreated injury.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-6 with combination
    Study

    humann: not reported in source

    A549 cells with seawater injury
    Comparator
    Seawater injury without treatment
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    The contents of TNF-α and IL-6 also decreased in the S+D+C group (P<0.01).
    1 context sentence
    Summary · context
    The in vitro experiments with A549 cells were divided into 5 groups: blank control group (C), seawater injury group (S),

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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