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Study · Animal study (in vivo) · mouse · 2019

4 results

Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease.

Bermúdez ML, Seroogy KB, Genter MB

Neuroscience22 May 2019Cited by 27 (Europe PMC)

PMID31125602 (opens in a new tab)DOI10.1016/j.neuroscience.2019.05.026 (opens in a new tab)PepBankPUB-31125602
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Thy1-aSyn and wild-type BDF1 mice, intranasal carnosine did not affect olfactory function.

    In plain wordsIn Thy1-aSyn and wild-type mice, intranasal carnosine did not affect olfactory function.

    Peptide
    L-carnosine
    Outcome
    No significant changeOlfactory function with intranasal treatment
    Study

    mousen: not reported in source

    Thy1-aSyn and wild-type BDF1 mice
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    2 mg/day · intranasal · 2 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Olfactory function was unaffected by carnosine treatment via either administration route.
    1 context sentence
    Summary · context
    After 2 months of daily treatment with either intranasal (2 mg/day) or oral (10 mM in drinking water) carnosine, Thy1-aSyn mice and wild-type BDF1 mice were assessed for sensorimotor (challenging beam traversal test and spontaneous activity) and olfactory (buried pellet test) function.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Thy1-aSyn and wild-type BDF1 mice, oral carnosine did not affect olfactory function.

    In plain wordsIn Thy1-aSyn and wild-type mice, oral carnosine did not affect olfactory function.

    Peptide
    L-carnosine
    Outcome
    No significant changeOlfactory function with oral treatment
    Study

    mousen: not reported in source

    Thy1-aSyn and wild-type BDF1 mice
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    10 mM in drinking water · oral · 2 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Olfactory function was unaffected by carnosine treatment via either administration route.
    1 context sentence
    Summary · context
    After 2 months of daily treatment with either intranasal (2 mg/day) or oral (10 mM in drinking water) carnosine, Thy1-aSyn mice and wild-type BDF1 mice were assessed for sensorimotor (challenging beam traversal test and spontaneous activity) and olfactory (buried pellet test) function.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Thy1-aSyn mice, intranasal carnosine prevented the normal decline in gait function.

    In plain wordsIn mice, intranasal carnosine prevented the normal decline in gait function.

    Peptide
    L-carnosine
    Outcome
    IncreaseGait function
    Study

    mousen: not reported in source

    Thy1-aSyn mice
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2 mg/day · intranasal · 2 monthsAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, intranasal carnosine prevented the normal decline in gait function seen in the challenging beam test in the Thy1-aSyn mice.
    1 context sentence
    Summary · context
    After 2 months of daily treatment with either intranasal (2 mg/day) or oral (10 mM in drinking water) carnosine, Thy1-aSyn mice and wild-type BDF1 mice were assessed for sensorimotor (challenging beam traversal test and spontaneous activity) and olfactory (buried pellet test) function.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Thy1-aSyn mice, carnosine decreased olfactory epithelial aSyn immunostaining compared with vehicle.

    In plain wordsIn mice, carnosine decreased olfactory epithelial aSyn staining compared with vehicle.

    Peptide
    L-carnosine
    Outcome
    DecreaseOlfactory epithelial aSyn immunostaining
    Study

    mousen: not reported in source

    Thy1-aSyn mice
    Comparator
    Vehicle-treated Thy1-aSyn mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 2 monthsAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, carnosine-treated Thy1-aSyn mice exhibited decreased aSyn immunostaining in the olfactory epithelium compared to vehicle-treated Thy1-aSyn mice,
    1 context sentence
    Summary · context
    After 2 months of daily treatment with either intranasal (2 mg/day) or oral (10 mM in drinking water) carnosine, Thy1-aSyn mice and wild-type BDF1 mice were assessed for sensorimotor (challenging beam traversal test and spontaneous activity) and olfactory (buried pellet test) function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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