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Study · Animal study (in vivo) · rat · 2023

14 results

[Carnosine protects against diabetic nephropathy in rats by activating the AKT/mTOR pathway and restoring autophagy in the renal tissue].

Ren Y, Lu J, Yu L, Li Z, Wang G, Yang J

Nan fang yi ke da xue xue bao = Journal of Southern Medical University1 Nov 2023

PMID38081616 (opens in a new tab)PMCIDPMC10713464 (opens in a new tab)DOI10.12122/j.issn.1673-4254.2023.11.18 (opens in a new tab)PepBankPUB-38081616
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine produced dry hair with normal luster versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine produced dry hair with normal luster versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    Not applicableHair appearance
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine increased body weight versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine increased body weight versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    IncreaseBody weight
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine slightly decreased blood glucose versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine slightly decreased blood glucose versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseBlood glucose
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine slightly decreased urinary protein content versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine slightly decreased urinary protein content versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseUrinary protein
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine slightly decreased 24-h urine volume versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine slightly decreased 24-h urine volume versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    Decrease24-h urine volume
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine slightly decreased blood creatinine versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine slightly decreased blood creatinine versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseBlood creatinine
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine slightly decreased kidney mass versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine slightly decreased kidney mass versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseKidney mass
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The diabetic rats receiving carnosine treatments had dry hair with normal luster and showed increased body weight and slightly decreased blood glucose, urinary protein content, 24-h urine volume, blood creatinine, and kidney mass.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic rats, carnosine improved renal pathology versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine improved renal pathology versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal pathological injury
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine increased renal SOD activity versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine increased renal SOD activity versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    IncreaseRenal SOD activity
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine decreased renal MDA content versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine decreased renal MDA content versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal MDA content
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine increased the renal p-mTOR/mTOR ratio versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine increased the renal p-mTOR/mTOR ratio versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    Increasep-mTOR/mTOR ratio
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine increased the renal p-AKT/AKT ratio versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine increased the renal p-AKT/AKT ratio versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    Increasep-AKT/AKT ratio
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine lowered the renal LC3 Ⅱ/Ⅰ ratio versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine lowered the renal LC3 Ⅱ/Ⅰ ratio versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    DecreaseLC3 II/I ratio
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In diabetic rats, carnosine lowered renal p62 protein expression versus untreated diabetic rats.

    In plain wordsIn diabetic rats, carnosine lowered renal p62 protein expression versus untreated diabetic rats.

    Peptide
    L-carnosine
    Outcome
    Decreasep62 expression
    Study

    ratn: not reported in source

    High-fat diet and streptozotocin-induced diabetes
    Comparator
    Diabetic rats without carnosine
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    100, 300, and 900 mg/kg dailyAs given in this study (rat).

    Source sentences

    Summary
    The treatment also improved renal pathology, increased SOD activity, decreased MDA content, increased p-mTOR/mTOR and p-AKT/AKT ratios and lowered LC3 Ⅱ/Ⅰ ratio and p62 protein expression in renal tissue of the diabetic rats.
    1 context sentence
    Summary · context
    Rat models of DM established by high-fat diet feeding and streptozotocin injection were randomized into DM group and 3 treatment groups with daily carnosine treatment at 100, 300, and 900 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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