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Study · Animal study (in vivo) · mouse · 2018

12 results

Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage.

Deng J, Zhong YF, Wu YP, Luo Z, Sun YM, Wang GE, Kurihara H, Li YF, He RR

Redox biology4 Aug 2017Cited by 69 (Europe PMC)

PMID28826042 (opens in a new tab)PMCIDPMC5565745 (opens in a new tab)DOI10.1016/j.redox.2017.08.003 (opens in a new tab)PepBankPUB-28826042
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In cyclophosphamide-treated mice, carnosine significantly inhibited bone marrow reactive oxygen species generation.

    In plain wordsIn mice, carnosine reduced bone marrow reactive oxygen species compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseReactive oxygen species generation
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In cyclophosphamide-treated mice, carnosine significantly inhibited bone marrow 8-oxo-dG generation.

    In plain wordsIn mice, carnosine reduced bone marrow 8-oxo-dG compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    Decrease8-oxo-dG generation
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-treated mice, carnosine decreased bone marrow chromosomal abnormalities.

    In plain wordsIn mice, carnosine reduced bone marrow chromosome abnormalities compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseChromosomal abnormalities
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In murine bone marrow cells, carnosine mitigated cyclophosphamide-induced G2/M arrest.

    In plain wordsIn mice, carnosine reduced bone marrow G2/M arrest compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseG2/M arrest
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, carnosine evidently mitigated CTX-induced G2/M arrest in murine bone marrow cells, accompanied by reduced ratios of p-Chk1/Chk1 and p-p53/p53 as well as decreased p21 expression.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In murine bone marrow cells, carnosine reduced the p-Chk1/Chk1 ratio after cyclophosphamide.

    In plain wordsIn mice, carnosine reduced the bone marrow p-Chk1/Chk1 ratio compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    Decreasep-Chk1/Chk1 ratio
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, carnosine evidently mitigated CTX-induced G2/M arrest in murine bone marrow cells, accompanied by reduced ratios of p-Chk1/Chk1 and p-p53/p53 as well as decreased p21 expression.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In murine bone marrow cells, carnosine reduced the p-p53/p53 ratio after cyclophosphamide.

    In plain wordsIn mice, carnosine reduced the bone marrow p-p53/p53 ratio compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    Decreasep-p53/p53 ratio
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, carnosine evidently mitigated CTX-induced G2/M arrest in murine bone marrow cells, accompanied by reduced ratios of p-Chk1/Chk1 and p-p53/p53 as well as decreased p21 expression.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In murine bone marrow cells, carnosine decreased p21 expression after cyclophosphamide.

    In plain wordsIn mice, carnosine reduced bone marrow p21 expression compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    Decreasep21 expression
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, carnosine evidently mitigated CTX-induced G2/M arrest in murine bone marrow cells, accompanied by reduced ratios of p-Chk1/Chk1 and p-p53/p53 as well as decreased p21 expression.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    Carnosine suppressed cyclophosphamide-induced apoptosis in murine bone marrow cells.

    In plain wordsIn mice, carnosine reduced bone marrow cell death compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, cell apoptosis caused by CTX was also suppressed by carnosine treatment, as assessed by decreased TUNEL-positive cell counts, down-regulated expressions of Bax and Cyt c, and reduced ratios of cleaved Caspase-3/Caspase-3.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  9. 09AnimalAnimal study (in vivo)Mechanism

    Carnosine decreased TUNEL-positive bone marrow cell counts in cyclophosphamide-treated mice.

    In plain wordsIn mice, carnosine reduced TUNEL-positive bone marrow cells compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseTUNEL-positive cell counts
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, cell apoptosis caused by CTX was also suppressed by carnosine treatment, as assessed by decreased TUNEL-positive cell counts, down-regulated expressions of Bax and Cyt c, and reduced ratios of cleaved Caspase-3/Caspase-3.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  10. 10AnimalAnimal study (in vivo)Mechanism

    Carnosine reduced Bax expression in bone marrow cells of cyclophosphamide-treated mice.

    In plain wordsIn mice, carnosine reduced bone marrow Bax expression compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseBax expression
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, cell apoptosis caused by CTX was also suppressed by carnosine treatment, as assessed by decreased TUNEL-positive cell counts, down-regulated expressions of Bax and Cyt c, and reduced ratios of cleaved Caspase-3/Caspase-3.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  11. 11AnimalAnimal study (in vivo)Mechanism

    Carnosine reduced Cyt c expression in bone marrow cells of cyclophosphamide-treated mice.

    In plain wordsIn mice, carnosine reduced bone marrow Cyt c expression compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseCyt c expression
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, cell apoptosis caused by CTX was also suppressed by carnosine treatment, as assessed by decreased TUNEL-positive cell counts, down-regulated expressions of Bax and Cyt c, and reduced ratios of cleaved Caspase-3/Caspase-3.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).
  12. 12AnimalAnimal study (in vivo)Mechanism

    Carnosine reduced the cleaved Caspase-3/Caspase-3 ratio in bone marrow cells of cyclophosphamide-treated mice.

    In plain wordsIn mice, carnosine reduced the bone marrow cleaved Caspase-3/Caspase-3 ratio compared with cyclophosphamide without carnosine.

    Peptide
    L-carnosine
    Outcome
    DecreaseCleaved Caspase-3/Caspase-3 ratio
    Study

    mousen: not reported in source

    cyclophosphamide-treated mice, bone marrow cells
    Comparator
    cyclophosphamide without carnosine
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    100 and 200 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, cell apoptosis caused by CTX was also suppressed by carnosine treatment, as assessed by decreased TUNEL-positive cell counts, down-regulated expressions of Bax and Cyt c, and reduced ratios of cleaved Caspase-3/Caspase-3.
    1 context sentence
    Summary · context
    Our results show that carnosine treatment (100 and 200mg/kg, i.p.) significantly inhibited the generation of reactive oxygen species (ROS) and 8-hydroxy-2'-deoxyguanosine (8-oxo-dG), and decreased chromosomal abnormalities in the bone marrow cells of mice treated with CTX (20mg/kg, i.v., 24h).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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